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. 2024 Jul;310(1):433-439.
doi: 10.1007/s00404-024-07453-x. Epub 2024 Mar 27.

Evaluation of systemic immune-inflammation index for predicting late-onset fetal growth restriction

Fahri Burcin Firatligil  1 , Serap Topkara Sucu  2 , Sitare Tuncdemir  2 , Erkan Saglam  3 , Murat Levent Dereli  3 , Sadullah Ozkan  3 , Yildiz Akdas Reis  4 , Kadriye Yakut Yucel  3 , Sevki Celen  3 , Ali Turhan Caglar  3
Affiliations

Evaluation of systemic immune-inflammation index for predicting late-onset fetal growth restriction

Fahri Burcin Firatligil et al. Arch Gynecol Obstet. 2024 Jul.

Abstract

Introduction: To determine a cut-off value for systemic immune-inflammation index (SII) (neutrophil × platelet/lymphocyte) in the prediction of fetal growth restriction (FGR).

Materials and methods: This case-control study was conducted retrospectively at the Obstetrics-Gynecology and Perinatology Clinics of Etlik Zubeyde Hanim Women's Health Education and Training Hospital. Singleton pregnant women with late-onset FGR who were followed up in outpatient clinics or hospitalized and whose pregnancy resulted at our hospital were included in the study group (group I). Healthy early and full-term singleton pregnant women with spontaneous labor who were followed up in the same hospital and whose pregnancy resulted at the same hospital were included in the control group (group II). Receiver-operating characteristic curves were used to assess the performance of SII value in predicting FGR.

Results: We recruited 79 cases (pregnant with late-onset fetal growth restriction) and 79 controls (healthy pregnant), matched for age, body mass index, and parity. ΔSII was statistically significantly higher in the pregnant with late-onset FGR compared with healthy pregnant (123 vs - 65; p = 0.039). The values in ROC curves with the best balance of sensitivity/specificity were > 152 109/L (49% sensitivity, 70% specificity) and > 586 109/L (27% sensitivity, 90% specificity) for late-onset FGR.

Discussion: Higher ΔSII levels in maternal blood indicate an inflammatory process causing FGR. The cut-off value for ΔSII (> 586 109/L) at 90% specificity can be used as a screening test. In the presence of ΔSII levels > 586 109/L (27% sensitivity and 90% specificity), the physicians should be more cautious about risk for FGR. Therefore, pregnant women at risk for FGR should be checked more frequently and monitored closely. However, further studies are needed to confirm our findings.

Keywords: Fetal growth restriction; Platelet; Pregnancy; Systemic immune-inflammation index.

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