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Meta-Analysis
. 2024 May;42(3):316-325.
doi: 10.1007/s00774-024-01500-y. Epub 2024 Mar 27.

Effectiveness of calcimimetics on fractures in dialysis patients with secondary hyperparathyroidism: meta-analysis of randomized trials

Takuya Wakamatsu  1 , Suguru Yamamoto  2 , Koji Matsuo  3 , Masatomo Taniguchi  4 , Takayuki Hamano  5   6 , Masafumi Fukagawa  7 , Junichiro James Kazama  8
Affiliations
Meta-Analysis

Effectiveness of calcimimetics on fractures in dialysis patients with secondary hyperparathyroidism: meta-analysis of randomized trials

Takuya Wakamatsu et al. J Bone Miner Metab. 2024 May.

Abstract

Introduction: This study aimed to assess the effectiveness of calcimimetics in reducing the risk of fractures in dialysis patients with secondary hyperparathyroidism (SHPT).

Material and methods: A comprehensive literature search was conducted using PubMed, Embase, and Cochrane Library for articles published through December 9, 2023. The quality of each trial was evaluated using the Cochrane Collaboration tool. Meta-analysis was performed using a random-effects model, and effect measures across studies were synthesized. The risk ratio (RR) and 95% confidence interval (CI) were used to quantify the risk of fracture.

Results: We identified seven studies involving 6481 dialysis patients with SHPT. The administration of calcimimetics reduced fracture incidence compared to placebo or conventional treatment (RR: 0.50, 95% CI 0.29-0.88, p = 0.02). Calcimimetics demonstrated a low number needed to treat (NNT) to prevent an incident fracture (NNT: 47).

Conclusion: The use of calcimimetics offers a significant benefit in reducing the risk of fractures in patients undergoing dialysis with SHPT.

Keywords: Calcimimetics; Dialysis; Fracture; Meta-analysis; Parathyroid hormone.

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