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. 2024 Jul 1;110(7):4023-4030.
doi: 10.1097/JS9.0000000000001401.

Clinicopathologic characteristics and outcomes of prostate cancer incidentally discovered at the time of radical cystoprostatectomy: a population-based cohort study

Kan Wu  1 , Xu Liu  2 , Yaxiong Tang  1 , Xianding Wang  1 , Xiang Li  1
Affiliations

Clinicopathologic characteristics and outcomes of prostate cancer incidentally discovered at the time of radical cystoprostatectomy: a population-based cohort study

Kan Wu et al. Int J Surg. .

Abstract

Objective: This study aimed to comprehensively analyze the clinical characteristics and prognosis of patients with concomitant bladder cancer (BCa) and prostate cancer (PCa) using a large population-based database.

Methods: Within the Surveillance, Epidemiology, and End Results (SEER) database (2000-2019), the authors identified patient with concomitant PCa at the time of radical cystoprostatectomy (RCP). Logistic regression and propensity score matching (PSM) analyses were employed to identify risk factors and mitigate confounders, respectively. Kaplan-Meier survival curves were used to estimate cancer-specific survival (CSS).

Results: A total of 14 199 BCa patients undergoing RCP were identified, with 28.8% incidentally discovered to have concurrent PCa. Among them, 89.9% exhibited organ-confined (T1-2) PCa. An increased risk of concomitant tumors was observed among older age, white race, and high tumor grade of BCa. Survival analysis revealed no significant difference in CSS between patients with BCa alone and those with concurrent PCa (5-year CSS rate: 71.3 vs. 67.2%, P =0.076). Subgroup analysis and multivariable analysis, however, indicated that concurrent high-risk PCa adversely impacted survival (5-year CSS rate: 71.3 vs. 63.4%, HR 1.27, 95% CI: 1.01-1.58, P =0.038) compared to solitary BCa. Notably, the presence of low/intermediate-risk PCa did not affect survival outcomes ( P =0.584).

Conclusion: In conclusion, incidentally discovered PCa in RCP specimens is frequent and characterized by organ-confined presentation, lower PSA levels, and Gleason scores. Patients with concurrent high-risk PCa have a worse prognosis compared to those with solitary BCa, while the presence of low/intermediate-risk PCa does not influence oncological prognosis.

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Conflict of interest statement

The authors have no potential conflicts of interest to disclose.

Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article.

Figures

Figure 1
Figure 1
Cancer-specific survival of patients who initially presented with solitary bladder cancer (BCa) or concomitant BCa and prostate cancer (PCa).
Figure 2
Figure 2
Cancer-specific survival of patients who initially presented with solitary bladder cancer (BCa) or synchronous concomitant BCa and prostate cancer (PCa) based on the EAU risk stratification for localized PCa.
None
None
See this image and copyright information in PMC

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References

    1. Luchey AM, Lin HY, Yue B, et al. . Implications of definitive prostate cancer therapy on soft tissue margins and survival in patients undergoing radical cystectomy for bladder urothelial cancer. J Urol 2015;194:1220–1225. - PubMed
    1. Barbisan F, Mazzucchelli R, Scarpelli M, et al. . Urothelial and incidental prostate carcinoma in prostates from cystoprostatectomies for bladder cancer: is there a relationship between urothelial and prostate cancer? BJU Int 2009;103:1058–1063. - PubMed
    1. Lopez-Beltran A, Cheng L, Montorsi F, et al. . Concomitant bladder cancer and prostate cancer: challenges and controversies. Nat Rev Urol 2017;14:620–629. - PubMed
    1. Qarro A, Ammani A, Bazine K, et al. . Synchronous primary malignancies of the male urogenital tract. Can Urol Assoc J 2014;8:E353–E355. - PMC - PubMed
    1. Shariat SF, Sfakianos JP, Droller MJ, et al. . The effect of age and gender on bladder cancer: a critical review of the literature. BJU Int 2010;105:300–308. - PMC - PubMed