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. 2024 Jul 1;110(7):4132-4142.
doi: 10.1097/JS9.0000000000001325.

Long-term survival outcomes of robotic total gastrectomy for locally advanced proximal gastric cancer: a prospective study

Qing Zhong  1   2   3 , Yi-Hui Tang  1   2   3 , Zhi-Yu Liu  1   2   3 , Zhi-Quan Zhang  1   2   3 , Qi-Chen He  1   2   3 , Ping Li  1   2   3 , Jian-Wei Xie  1   2   3 , Jia-Bin Wang  1   2   3 , Jian-Xian Lin  1   2   3 , Jun Lu  1   2   3 , Qi-Yue Chen  1   2   3 , Chao-Hui Zheng  1   2   3 , Chang-Ming Huang  1   2   3
Affiliations

Long-term survival outcomes of robotic total gastrectomy for locally advanced proximal gastric cancer: a prospective study

Qing Zhong et al. Int J Surg. .

Abstract

Background: Robotic gastrectomy is a safe and feasible approach for gastric cancer (GC); however, its long-term oncological efficacy remains unclear. The authors evaluated the long-term survival outcomes and recurrence patterns of patients with locally advanced proximal GC who underwent robotic total gastrectomy (RTG).

Methods: This prospective study (FUGES-014 study) enrolled 48 patients with locally advanced proximal GC who underwent RTG between March 2018 and February 2020 at a tertiary referral teaching hospital. Patients who underwent laparoscopic total gastrectomy (LTG) in the FUGES-002 study were enrolled in a 2:1 ratio to compare the survival outcomes between RTG and LTG. The primary endpoint of the FUGES-014 study was postoperative 30-day morbidity and has been previously reported. Here, the authors reported the results of 3-year disease-free survival (DFS), 3-year overall survival (OS), and recurrence patterns.

Results: After propensity score matching, 48 patients in the RTG and 96 patients in the LTG groups were included. The 3-year DFS rates were 77.1% (95% CI: 66.1-89.9%) for the RTG and 68.8% (95% CI: 60.1-78.7%) for the LTG groups ( P =0.261). The 3-year OS rates were not significantly different between the groups (85.4 vs. 74.0%, P =0.122). Recurrence occurred in nine patients (18.8%) in the RTG and 27 (28.1%) patients in the LTG groups ( P =0.234). Recurrence patterns and causes of death were similar between the groups ( P >0.05).

Conclusions: The oncological outcome of RTG was noninferior to that of LTG. Thus, RTG might be an alternative surgical treatment for locally advanced proximal GC.

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Conflict of interest statement

None reported.

Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article.

Figures

Figure 1
Figure 1
Patient enrollment.
Figure 2
Figure 2
Kaplan–Meier curves comparing disease-free survival (A) and overall survival (B) between patients in the robotic and laparoscopic groups.
Figure 3
Figure 3
Kaplan–Meier curves comparing disease-free survival, overall survival, and cumulative recurrence between patients with stage I (A), stage II (B), or stage III (C) tumors in the robotic and laparoscopic groups.
See this image and copyright information in PMC

References

    1. Sung H, Ferlay J, Siegel R, et al. . Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2021;71:209–249. - PubMed
    1. Songun I, Putter H, Kranenbarg E, et al. . Surgical treatment of gastric cancer: 15-year follow-up results of the randomised nationwide Dutch D1D2 trial. Lancet Oncol 2010;11:439–449. - PubMed
    1. Huang C, Liu H, Hu Y, et al. . Laparoscopic vs open distal gastrectomy for locally advanced gastric cancer: five-year outcomes from the CLASS-01 randomized clinical trial. JAMA Surg 2022;157:9–17. - PMC - PubMed
    1. Kim H, Han S, Kim M, et al. . Effect of laparoscopic distal gastrectomy vs open distal gastrectomy on long-term survival among patients with stage i gastric cancer: the KLASS-01 randomized clinical trial. JAMA Oncol 2019;5:506–513. - PMC - PubMed
    1. Son S, Hur H, Hyung W, et al. . Laparoscopic vs open distal gastrectomy for locally advanced gastric cancer: 5-year outcomes of the KLASS-02 randomized clinical trial. JAMA Surg 2022;157:879–886. - PMC - PubMed