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. 2024 Mar 27;20(1):26.
doi: 10.1186/s13223-023-00858-4.

Elevated tryptase level in a child with idiopathic anaphylaxis: a case of hereditary alpha-tryptasemia

Vicky Le Blanc  1 , Wade T A Watson  2
Affiliations

Elevated tryptase level in a child with idiopathic anaphylaxis: a case of hereditary alpha-tryptasemia

Vicky Le Blanc et al. Allergy Asthma Clin Immunol. .

Abstract

Hereditary alpha-tryptasemia (HαT) is an autosomal dominant disorder estimated to affect 5% of the population. High baseline tryptase level is a consistent finding, but there is a great variability of clinic manifestations, including no symptoms at all. We describe a case of HαT in a 5 years 8 months old girl manifesting with idiopathic anaphylaxis and elevated baseline tryptase level. As more cases of HαT are described, a better understanding of the clinical phenotype will be acquired.

Keywords: Elevated tryptase level; Hereditary alpha-tryptasemia; Idiopathic anaphylaxis.

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Conflict of interest statement

The authors declare that they have no competing interests.

References

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