doi: 10.1126/science.3854.
Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs
- PMID: 3854
- DOI: 10.1126/science.3854
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Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs
Science.
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Abstract
Tritiated haloperidol and tritiated dopamine label postsynaptic dopamine receptors in mammalian brain. Clinical potencies of butyrophenones, phenothiazines, and related drugs correlate closely with their ability to inhibit tritiated haloperidol binding. These binding methods provide a simple in vitro means for evaluating new drugs as potential antischizophrenic agents.
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