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. 1976 Apr 30;192(4238):481-3.
doi: 10.1126/science.3854.

Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs

I Creese, D R Burt, S H Snyder

Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs

I Creese et al. Science. .

Abstract

Tritiated haloperidol and tritiated dopamine label postsynaptic dopamine receptors in mammalian brain. Clinical potencies of butyrophenones, phenothiazines, and related drugs correlate closely with their ability to inhibit tritiated haloperidol binding. These binding methods provide a simple in vitro means for evaluating new drugs as potential antischizophrenic agents.

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