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Review
. 2024 Mar 6;12(3):585.
doi: 10.3390/biomedicines12030585.

The Perspectives of Platelet Proteomics in Health and Disease

Preeti Kumari Chaudhary  1 , Sachin Upadhayaya  1 , Sanggu Kim  1 , Soochong Kim  1
Affiliations
Review

The Perspectives of Platelet Proteomics in Health and Disease

Preeti Kumari Chaudhary et al. Biomedicines. .

Abstract

Cardiovascular thromboembolic diseases and cancer continue to be a leading cause of death and disability worldwide. Therefore, it is crucial to advance their diagnoses and treatment in the context of individualized medicine. However, the disease specificity of the currently available markers is limited. Based on analyses of a subset of peptides and matching proteins in disease vs. healthy platelets, scientists have recently shown that focused platelet proteomics enables the quantification of disease-specific biomarkers in humans. In this review, we explored the potential of accurate platelet proteomic research, which is required to identify novel diagnostic and pharmaceutical targets by comprehending the proteome variety of healthy individuals and patients for personalized and precision medicine.

Keywords: CVDs; cancer; platelet; proteomics; transfusion.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Overall signaling mechanism of platelet activation.
Figure 2
Figure 2
Schematic diagram of platelet proteomics and its application.
See this image and copyright information in PMC

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References

    1. Chaudhary P.K., Kim S., Kim S. An insight into recent advances on platelet function in health and disease. Int. J. Mol. Sci. 2022;23:6022. doi: 10.3390/ijms23116022. - DOI - PMC - PubMed
    1. Villa-Fajardo M., Palma M.C.Y., Acebes-Huerta A., Martínez-Botía P., Meinders M., Nolte M.A., Cuesta C.B., Eble J.A., Del Castillo J.G., Martín-Sánchez F.J. Platelet number and function alterations in preclinical models of sterile inflammation and sepsis patients: Implications in the pathophysiology and treatment of inflammation. Transfus. Apher. Sci. 2022;61:103413. doi: 10.1016/j.transci.2022.103413. - DOI - PubMed
    1. Gianazza E., Brioschi M., Baetta R., Mallia A., Banfi C., Tremoli E. Platelets in healthy and disease states: From biomarkers discovery to drug targets identification by proteomics. Int. J. Mol. Sci. 2020;21:4541. doi: 10.3390/ijms21124541. - DOI - PMC - PubMed
    1. Antunes-Ferreira M., Koppers-Lalic D., Würdinger T. Circulating platelets as liquid biopsy sources for cancer detection. Mol. Oncol. 2021;15:1727–1743. doi: 10.1002/1878-0261.12859. - DOI - PMC - PubMed
    1. Humphrey J. Origin of blood platelets. Nature. 1955;176:38. doi: 10.1038/176038a0. - DOI - PubMed

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