Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Mar 14;13(6):885.
doi: 10.3390/foods13060885.

Preparation, Biological Activities, and Potential Applications of Hen Egg-Derived Peptides: A Review

Li Song  1 , Yi Chen  1 , Huiping Liu  1 , Xiaowei Zhang  1
Affiliations
Review

Preparation, Biological Activities, and Potential Applications of Hen Egg-Derived Peptides: A Review

Li Song et al. Foods. .

Abstract

Food-derived peptides have been extensively studied for their benefits in humans. Hen eggs, characterized by high protein and digestibility, are an excellent source of food-derived bioactive peptides. This review summarizes the preparation methods, purification, and identification of hen egg-derived peptides (HEPs). The preparation methods mainly include enzymatic hydrolysis, microbial fermentation, and chemical synthesis. Genetic engineering is an emerging trend of HEP preparation. Then, we summarize the biological activities of HEPs, such as antioxidant activities, enzyme inhibitory activity, and antibacterial activity, of which the enzyme inhibitory activity is comprehensively summarized for the first time. The structure-activity relationship and underlying mechanism of the HEPs are further elucidated. Finally, the applications, future challenges, and opportunities of HEPs were mainly discussed in the food and non-food sectors. We focus on the potential applications of HEPs in intestinal health and assembly delivery and provide a reference for the further utilization and commercial development of HEPs.

Keywords: co-delivery system; egg-derived peptides; enzyme inhibitors; intestinal health.

PubMed Disclaimer

Conflict of interest statement

All authors declare that they have no known competing interests.

Figures

Figure 1
Figure 1
Application of HEPs in the food and non-food sectors.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. OECD. Food and Agriculture Organization of the United Nations . OECD-FAO Agricultural Outlook 2023–2032. OECD; Paris, France: 2023. OECD-FAO Agricultural Outlook.
    1. Lesnierowski G., Stangierski J. What’s New in Chicken Egg Research and Technology for Human Health Promotion?—A Review. Trends Food Sci. Technol. 2018;71:46–51. doi: 10.1016/j.tifs.2017.10.022. - DOI
    1. Puglisi M.J., Fernandez M.L. The Health Benefits of Egg Protein. Nutrients. 2022;14:2904. doi: 10.3390/nu14142904. - DOI - PMC - PubMed
    1. Kulshreshtha G., Diep T., Hudson H.-A., Hincke M.T. High Value Applications and Current Commercial Market for Eggshell Membranes and Derived Bioactives. Food Chem. 2022;382:132270. doi: 10.1016/j.foodchem.2022.132270. - DOI - PubMed
    1. Sarantidi E., Ainatzoglou A., Papadimitriou C., Stamoula E., Maghiorou K., Miflidi A., Trichopoulou A., Mountzouris K.C., Anagnostopoulos A.K. Egg White and Yolk Protein Atlas: New Protein Insights of a Global Landmark Food. Foods. 2023;12:3470. doi: 10.3390/foods12183470. - DOI - PMC - PubMed

LinkOut - more resources