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Review
. 2024 Mar 7;13(6):1537.
doi: 10.3390/jcm13061537.

The Physical and Psychosocial Impact of Fatigue among Patients with Sjogren's Syndrome: A Systematic Review

Denise-Ani Mardale  1   2 , Daniela Opriș-Belinski  1   2 , Violeta Bojincă  1   2 , Mihai Bojincă  1   3 , Diana Mazilu  1   2 , Emilia Păsăran  1 , Cristina Nițăa  1 , Laura Groșeanu  1   2 , Florian Berghea  1   2 , Andra-Rodica Bălănescu  1   2
Affiliations
Review

The Physical and Psychosocial Impact of Fatigue among Patients with Sjogren's Syndrome: A Systematic Review

Denise-Ani Mardale et al. J Clin Med. .

Abstract

Background: Primary Sjögren's syndrome (pSS) is a complex autoimmune disorder characterized by organ-specific symptoms in the salivary and lacrimal glands, as well as systemic manifestations. Fatigue, a prominent aspect, significantly influences the overall quality of life for individuals with pSS. Methods: This review seeks to evaluate the impact of fatigue by exploring its consequences, potential causes, and effects on physical and psychological well-being, while also investigating its management strategies. Following the "Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)" guidelines, our systematic literature review involved a five-step algorithm. Initially identifying 78 articles in reputable international medical databases, we applied eligibility criteria and removed duplicates, resulting in 19 articles for qualitative synthesis. Results: This review delves into the predictive factors for heightened fatigue in pSS, encompassing rheumatoid factor levels, erythrocyte sedimentation rate, and immunoglobulin G levels. Sleep disturbances, specifically nighttime pain and nocturia, emerged as determinants of persistent daytime fatigue. Cognitive impairment in pSS involves deteriorations in global memory, executive functioning, and attentional resources. Furthermore, functional limitations in pSS impact patients' quality of life. Conclusions: The significance of fatigue in pSS, its consequences, and profound influence on the quality of life necessitate further research for a more comprehensive understanding of this complex issue.

Keywords: cognitive concerns; fatigue; predictive factors; primary Sjogren’s syndrome; sleep disturbance.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
PRSIMA diagram—customized to our systematic literature review.
Figure 2
Figure 2
The correlation between different sleep-related symptoms and fatigue among patients with pSS.
Figure 3
Figure 3
The range of cognitive impairment types seen in pSS patients.
Figure 4
Figure 4
Diverse pathways underlying an innovative approach to managing fatigue in primary Sjögren’s syndrome patients.
See this image and copyright information in PMC

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