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Review
. 2024 Mar 12;25(6):3216.
doi: 10.3390/ijms25063216.

Intradermal Injection of Hybrid Complexes of High- and Low-Molecular-Weight Hyaluronan: Where Do We Stand and Where Are We Headed in Regenerative Medicine?

Dalvi Humzah  1 , Beatriz Molina  2 , Giovanni Salti  3 , Clara Cigni  4 , Gilberto Bellia  4 , Franco Grimolizzi  4
Affiliations
Review

Intradermal Injection of Hybrid Complexes of High- and Low-Molecular-Weight Hyaluronan: Where Do We Stand and Where Are We Headed in Regenerative Medicine?

Dalvi Humzah et al. Int J Mol Sci. .

Abstract

Hyaluronic acid (HA) is a remarkably multifaceted biomacromolecule, playing a role in regulating myriad biological processes such as wound healing, tissue regeneration, anti-inflammation, and immunomodulation. Crosslinked high- and low-molecular-weight hyaluronic acid hydrogels achieve higher molar concentrations, display slower degradation, and allow optimal tissue product diffusion, while harnessing the synergistic contribution of different-molecular-weight hyaluronans. A recent innovation in the world of hyaluronic acid synthesis is represented by NAHYCO® Hybrid Technology, a thermal process leading to hybrid cooperative hyaluronic acid complexes (HCC). This review summarizes the current literature on the in vitro studies and in vivo applications of HCC, from facial and body rejuvenation to future perspectives in skin wound healing, dermatology, and genitourinary pathologies.

Keywords: bioremodeling; filler; hyaluronic acid; hybrid cooperative complexes; hydrogel; rejuvenation.

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Conflict of interest statement

C.C., G.B., & F.G. are employees of IBSA Farmaceutici Italia Srl. The other authors declare that this research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Figures

Figure 1
Figure 1
NAHYCO® Hybrid Technology HCC production process.
Figure 2
Figure 2
HCCs across different tissue types.
Figure 3
Figure 3
Clinical evidence of intradermal injection of HCCs based on the literature with aesthetic indications and promising therapeutic applications.
See this image and copyright information in PMC

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