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Review
. 2024 Mar 20;25(6):3511.
doi: 10.3390/ijms25063511.

Cell Heterogeneity and Variability in Peripheral Nerve after Injury

Zhixian Ren  1 , Ya Tan  1 , Lili Zhao  1
Affiliations
Review

Cell Heterogeneity and Variability in Peripheral Nerve after Injury

Zhixian Ren et al. Int J Mol Sci. .

Abstract

With the development of single-cell sequencing technology, the cellular composition of more and more tissues is being elucidated. As the whole nervous system has been extensively studied, the cellular composition of the peripheral nerve has gradually been revealed. By summarizing the current sequencing data, we compile the heterogeneities of cells that have been reported in the peripheral nerves, mainly the sciatic nerve. The cellular variability of Schwann cells, fibroblasts, immune cells, and endothelial cells during development and disease has been discussed in this review. The discovery of the architecture of peripheral nerves after injury benefits the understanding of cellular complexity in the nervous system, as well as the construction of tissue engineering nerves for nerve repair and axon regeneration.

Keywords: Schwann cells; axon regeneration; peripheral nerve system; sciatic nerve injury; single-cell RNA sequence.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Model of cell composition at the site of axon regeneration after peripheral nerve injury. (A) Longitudinal section of the regeneration site of nerve. (B) Transverse section of the regeneration site of nerve. Repair SCs interacting with macrophages, repair fibroblasts, and repair endothelial cells to phagocytoze myelin debris, regrow microvessels, and build a bridge for guiding the sprouting axons.
See this image and copyright information in PMC

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