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Review
. 2024 Mar 7;12(3):278.
doi: 10.3390/vaccines12030278.

Anti-SARS-CoV-2 Vaccination and PIMS-TS-Friends or Foe? Case Reports and Literature Review

Violetta Opoka-Winiarska  1 , Izabela Morawska-Michalska  2 , Paulina Mertowska  3 , Krzysztof Gosik  3 , Olga Kądziołka  4 , Ewelina Grywalska  3
Affiliations
Review

Anti-SARS-CoV-2 Vaccination and PIMS-TS-Friends or Foe? Case Reports and Literature Review

Violetta Opoka-Winiarska et al. Vaccines (Basel). .

Abstract

Pediatric inflammatory, multisystem syndrome temporally associated with SARS-CoV-2 infection (PIMS-TS), also known as a multisystem inflammatory syndrome in children (MIS-C), is diagnosed in children who develop an inadequate inflammatory response after exposure to the SARS-CoV-2 virus. The pathogenesis of the abnormal response of the immune system to a previous SARS-COV-2 infection has not been explained. Similarly, the safety and effectiveness of COVID-19 vaccinations in this group of patients have become the subject of clinical discussion. Presenting experiences from many centers aims to answer this question. We present 4 cases of patients who suffered from PIMS-TS. Three of them were safely vaccinated against COVID-19 after illness. One patient developed PIMS-TS temporarily associated with COVID-19 vaccination. We also collected and discussed data from other centers.

Keywords: COVID-19; COVID-19 vaccination; MIS-C; PIMS-TS; SARS-CoV-2.

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Conflict of interest statement

The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

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