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. 2024 Mar 11;12(3):290.
doi: 10.3390/vaccines12030290.

Study on Varicella-Zoster Virus Antibody Levels among Children Aged 1-7 Years in Changzhou, China

Dan Wu  1   2 , Changlei Han  1   2 , Suting Xiong  1   2 , Peipei Zhang  1   2 , Han Gao  1   2 , Junhong Li  1 , Fengming Wang  1 , Qinwen Xu  3 , Xin Dong  1
Affiliations

Study on Varicella-Zoster Virus Antibody Levels among Children Aged 1-7 Years in Changzhou, China

Dan Wu et al. Vaccines (Basel). .

Abstract

We aim to understand the varicella-zoster virus (VZV) antibody levels in children after vaccination and to construct VZV-IgG centile curves and reference values for children aged 1-7 years. From September to October 2023, a total of 806 children were recruited according to the time intervals of 1 month, 6 months, 1 year, 2 years, and 3 years after vaccination, as well as age groups. A generalized additive model for location, shape, and scale (GAMLSS) was applied to estimate P3, P10, P25, P50, P75, P90, and P97 centile reference values of VZV-IgG, and 95% reference intervals were calculated. A total of 785 children were included in the analysis, with an overall positivity rate of 70.3%, a median antibody concentration of 192.05 (82.89-571.14) mIU/mL, and a positivity rate of 57.7% for one dose of vaccine and 84.2% for two doses. Antibody positivity rates at 1 month, 6 months, 1 year, 2 years, and 3 years after vaccination were 65.1%, 74.4%, 80.4%, 67.7%, and 63.0%, respectively. The GAMLSS results showed that VZV-IgG had a tendency to increase and then decrease after vaccination, and the second dose of vaccination could significantly increase VZV-IgG. Two doses of varicella vaccine should be administered to children in a timely manner and included in the routine vaccination programs.

Keywords: GAMLSS; VZV-IgG; vaccination; varicella.

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Conflict of interest statement

The authors declare no conflicts of interest. The funders had no role in the design of this study; in the collection, analyses, or interpretation of data; in the writing of this manuscript; or in the decision to publish the results.

Figures

Figure 1
Figure 1
Research flowchart.
Figure 2
Figure 2
Comparison of seropositivity rates for different doses at each time interval.
Figure 3
Figure 3
Variation in each parameter with age. (a–c) refer to the variations with age for μ, σ, and υ, respectively.
Figure 4
Figure 4
Centile curves for VZV-IgG (logarithmic) in children aged 1–7 years.
See this image and copyright information in PMC

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