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Clinical Trial
. 1979 Jul;20(7):624-8.
doi: 10.1136/gut.20.7.624.

Double-blind randomised clinical trial of a pepsin-inhibitory pentapeptide (pepstatin) in the treatment of duodenal ulcer

O Bonnevie, L B Svendsen, J Holst-Christensen, T S Johansen, J Søltoft, P M Christiansen
Clinical Trial

Double-blind randomised clinical trial of a pepsin-inhibitory pentapeptide (pepstatin) in the treatment of duodenal ulcer

O Bonnevie et al. Gut. 1979 Jul.

Abstract

In a double-blind randomised clinical trial a specific inhibition of peptic activity with a pentapeptide, pepstatin, had no significant advantage over placebo in the ulcer healing and symptomatology of duodenal ulcer. Thus, the inhibition of pepsin in human gastric juice does not appear to have a major influence on the healing of duodenal ulcer.

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