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Observational Study
. 2024 Mar;52(3):3000605241233520.
doi: 10.1177/03000605241233520.

Should atelectasis be considered a pulmonary complication and indicator of poor prognosis in cystic fibrosis?

María Martínez Redondo  1 , Carlos Carpio Segura  1 , Ester Zamarrón De Lucas  1 , Rodolfo Álvarez-Sala Walther  1 , Concepción Prados Sánchez  1
Affiliations
Observational Study

Should atelectasis be considered a pulmonary complication and indicator of poor prognosis in cystic fibrosis?

María Martínez Redondo et al. J Int Med Res. 2024 Mar.

Abstract

Objective: This study examined whether bronchoscopy leads to clinicoradiological improvement in cystic fibrosis (CF) and the predictive factors. The study also investigated whether pulmonary atelectasis is a poor prognostic factor in CF.

Methods: This multicenter, case-control, observational, retrospective study included two groups of patients with CF: a case group (patients with persistent atelectasis who were followed-up at least for 2 years) and a control group (patients without atelectasis matched 1:1 by sex and age [±3 years]). We recorded demographic data, lung function test results, pulmonary complications, comorbidities, treatments (including bronchoscopies, surgery and transplantation), and deaths.

Results: Each group included 55 patients (case group: 20 men, mean age 25.4 ± 10.4 years; control group: 20 men, mean age 26.1 ± 11.4 years). Bronchoscopy did not lead to clinicoradiological improvement. Allergic bronchopulmonary aspergillosis (ABPA) was more frequent in the case group. Patients in the case group more frequently used inhaled steroids, their pre-atelectasis lung function was statistically worse, and they had more exacerbations during follow-up.

Conclusion: Moderate-to-severe pulmonary disease and ABPA can favor atelectasis. Pulmonary atelectasis can be a poor prognostic factor in CF because it increases exacerbations. Despite our results, we recommend enhancing treatment, including bronchoscopy, to prevent persistent atelectasis.

Keywords: Cystic fibrosis; allergic bronchopulmonary aspergillosis; atelectasis; bronchoscopy; exacerbation; prognosis; risk factor.

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Conflict of interest statement

Declaration of conflicting interestThe authors declare that there are no conflicts of interest.

Figures

Figure 1.
Figure 1.
Rates of patients undergoing lung surgery and lung transplantation and the rate of death.
See this image and copyright information in PMC

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