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Clinical Trial
. 2024 Jul;99(7):1392-1395.
doi: 10.1002/ajh.27303. Epub 2024 Mar 28.

A phase 2 trial of orelabrutinib showing promising efficacy and safety in patients with persistent or chronic primary immune thrombocytopenia

Shi Yan  1 , Hu Zhou  2 , Ruibin Huang  3 , Fang Wang  4 , Heng Mei  5 , Lie Lin  6 , Jingming Guo  7 , Xin Zhou  8 , Zhenyu Li  9 , Yaorong Liu  10 , Sichen Li  11 , Wei Zhou  10 , Yu Hou  1 , Ming Hou  1
Affiliations
Free article
Clinical Trial

A phase 2 trial of orelabrutinib showing promising efficacy and safety in patients with persistent or chronic primary immune thrombocytopenia

Shi Yan et al. Am J Hematol. 2024 Jul.
Free article
No abstract available

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References

REFERENCES

    1. Rodeghiero F, Stasi R, Gernsheimer T, et al. Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group. Blood. 2009;113(11):2386‐2393.
    1. Lambert MP, Gernsheimer TB. Clinical updates in adult immune thrombocytopenia. Blood. 2017;129(21):2829‐2835.
    1. Pal Singh S, Dammeijer F, Hendriks RW. Role of Bruton's tyrosine kinase in B cells and malignancies. Mol Cancer. 2018;17(1):57.
    1. Yu T, Wang L, Ni X, Hou Y, Liu X, Hou M. Orelabrutinib, a selective Bruton's tyrosine kinase (BTK) inhibitor in the treatment of primary immune thrombocytopenia (ITP). Blood. 2021;138(Supplement 1):3172.
    1. Kuter DJ, Efraim M, Mayer J, et al. Rilzabrutinib, an Oral BTK inhibitor, in immune thrombocytopenia. N Engl J Med. 2022;386(15):1421‐1431.

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