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Review
. 2024 Apr;28(8):e18241.
doi: 10.1111/jcmm.18241.

Research progress of the netrins and their receptors in cancer

Xing Gao  1 , Jiazhou Ye  2 , Xi Huang  1 , Shilin Huang  1 , Wenfeng Luo  1 , Dandan Zeng  1 , Shizhou Li  2 , Minchao Tang  2 , Rongyun Mai  2 , Yongqiang Li  1 , Yan Lin  1 , Rong Liang  1
Affiliations
Review

Research progress of the netrins and their receptors in cancer

Xing Gao et al. J Cell Mol Med. 2024 Apr.

Abstract

Netrins, a family of secreted and membrane-associated proteins, can regulate axonal guidance, morphogenesis, angiogenesis, cell migration, cell survival, and tumorigenesis. Four secreted netrins (netrin 1, 3, 4 and 5) and two glycosylphosphatidylinositols-anchored membrane proteins, netrin-G1 and G2, have been identified in mammals. Netrins and their receptors can serve as a biomarker and molecular therapeutic target for pathological differentiation, diagnosis and prognosis of malignant cancers. We review here the potential roles of the netrins family and their receptors in cancer.

Keywords: cancer; membrane; netrins; receptor; secreted.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

FIGURE 1
FIGURE 1
Structure of netrins and their receptors. DCC, deleted in colorectal cancer; DSCAM, Down syndrome cell adhesion molecule; GPI, glycosylphosphatidylinositol.
FIGURE 2
FIGURE 2
Dependence receptors have two properties: when the ligand is present, binding to the ligand promotes cell survival, migration or differentiation. When the ligand is absent, it will induce apoptosis. The function of this receptor depends on the survival rate of its ligand. Binding of netrins to its receptors leads to multiple classic associated signalling pathway activation such as RAS/GTP, MAPK/ERK, FAK/ROCK and PI3K/AKT signalling.
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