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Clinical Trial
. 2024 Jul 1;109(7):2359-2363.
doi: 10.3324/haematol.2024.285207.

Elderly long-term survivors in the Nordic phase II study with first-line maintenance temozolomide for primary central nervous system lymphoma: a 10-year follow-up

Elisa Jacobsen Pulczynski  1 , Mikkel Runason Simonsen  2 , Outi Kuittinen  3 , Unn-Merete Fagerli  4 , Martin Erlanson  5 , Øystein Fluge  6 , Sirpa Leppä  7 , Bjørn Østenstad  8 , Alexander Fosså  9 , Mikael Eriksson  10 , Tarec El-Galaly  11 , Hanne Kuitunen  12 , Karin Papworth  5 , Maria Ljungqvist  13 , Martin B Pedersen  14 , Marjukka Pollari  15
Affiliations
Clinical Trial

Elderly long-term survivors in the Nordic phase II study with first-line maintenance temozolomide for primary central nervous system lymphoma: a 10-year follow-up

Elisa Jacobsen Pulczynski et al. Haematologica. .
No abstract available

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Figures

Figure 1.
Figure 1.
Overall survival, progression-free survival, and duration of response after complete remission. Long-term survival of patients and duration of complete remissions (CR). Demonstrative Kaplan-Meier curves depict (A) overall survival in the entire study population, (B) progression-free survival in the entire study population, (C) duration of response in the entire study population and differences in overall survival, progression-free survival, and duration of response between elderly and younger subgroups (D, E, and F, respectively).
See this image and copyright information in PMC

References

    1. Braggio E, Van Wier S, Ojha J, et al. . Genome-wide analysis uncovers novel recurrent alterations in primary central nervous system lymphomas. Clin Cancer Res. 2015;21(17):3986-3994. - PMC - PubMed
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    1. Mendez JS, Ostrom QT, Gittleman H, et al. . The elderly left behind-changes in survival trends of primary central nervous system lymphoma over the past 4 decades. Neuro Oncol. 2018;20(5):687-694. - PMC - PubMed
    1. Pulczynski EJ, Kuittinen O, Erlanson M, et al. . Successful change of treatment strategy in elderly patients with primary central nervous system lymphoma by de-escalating induction and introducing temozolomide maintenance: results from a phase II study by the Nordic Lymphoma Group. Haematologica. 2015;100(4):534-540. - PMC - PubMed
    1. Ferreri AJ, Blay JY, Reni MA, et al. . Prognostic scoring system for primary CNS lymphomas: the International Extranodal Lymphoma Study Group experience. J Clin Oncol 2003;21(2):266-272. - PubMed

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