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Multicenter Study
. 2024 Aug 1;109(8):2721-2725.
doi: 10.3324/haematol.2024.285031.

Non-myeloma light chain cast nephropathy: a multicenter retrospective study on clinicopathological characteristics

Ana Cristina Martins  1 , Jean-Baptiste Gibier  2 , Charles Ronsin  3 , Christine Kandel-Aznar  4 , Anne Moreau  5 , Marion Chapal  6 , Diogo Francisco  1 , Hamza Sakhi  7 , Julie Oniszczuk  8 , Lorraine Gueguen  9 , Anne Grunenwald  10 , Mathilde Devaux  11 , Alexandre Karras  12 , Virginie Royal  13 , Marion Rabant  14 , Viviane Gnemmi  2 , Jérôme Olagne  15 , Jean-Paul Duong Van Huyen  14 , Pierre Isnard  16
Affiliations
Multicenter Study

Non-myeloma light chain cast nephropathy: a multicenter retrospective study on clinicopathological characteristics

Ana Cristina Martins et al. Haematologica. .
No abstract available

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Figures

Figure 1.
Figure 1.
Pathology illustrations. (A) Representative image of a patient’s kidney biopsy viewed by light microscopy after staining with periodic acid-Schiff (PAS), showing multiple pale tubular casts with PAS staining (black arrows) and areas of interstitial infiltration (black asterisk). (B) Light microscopy after staining with Masson trichrome showing typical polychromatophilic casts with a giant cell reaction around a fractured cast (black arrow). (C) Light microscopy after hematoxylin & eosin staining showing diffuse interstitial lymphoma infiltration. (D) Immunohistochemistry analysis targeting CD79A showing diffuse interstitial B-cell lymphoma infiltration. (E ) Light microscopy after PAS staining of a biopsy from a patient with monoclonal immunoglobulin deposition disease (MIDD) and associated cast nephropathy showing PAS-positive mesangial expansion (red arrow) and PAS-positive tubular basement membrane thickening (black square) together with the presence of PAS-negative tubular casts (black arrows). (F, G) Immunofluorescence analyses of a patient with MIDD and associated cast nephropathy using anti-k and anti-A. antibodies showing monotypic k light chain staining within a tubular cast (red arrows), glomerular mesangium (yellow arrows) and tubular basement membrane (blue arrows). Scale bar 100 [im.
See this image and copyright information in PMC

References

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