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Review
. 2024 Mar 28;206(4):196.
doi: 10.1007/s00203-024-03899-4.

Cryosphere: a frozen home of microbes and a potential source for drug discovery

Sahib Zada #  1 , Mohsin Khan #  2 , Zheng Su  1 , Wasim Sajjad  3 , Muhammad Rafiq  4
Affiliations
Review

Cryosphere: a frozen home of microbes and a potential source for drug discovery

Sahib Zada et al. Arch Microbiol. .

Abstract

The world is concerned about the emergence of pathogens and the occurrence and spread of antibiotic resistance among pathogens. Drug development requires time to combat these issues. Consequently, drug development from natural sources is unavoidable. Cryosphere represents a gigantic source of microbes that could be the bioprospecting source of natural products with unique scaffolds as molecules or drug templates. This review focuses on the novel source of drug discovery and cryospheric environments as a potential source for microbial metabolites having potential medicinal applications. Furthermore, the problems encountered in discovering metabolites from cold-adapted microbes and their resolutions are discussed. By adopting modern practical approaches, the discovery of bioactive compounds might fulfill the demand for new drug development.

Keywords: Antibiotic resistance; Antimicrobial compounds; Cryosphere; Drug discovery; Novel microbes.

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References

    1. Afra S, Makhdoumi A, Matin MM, Feizy J (2017) A novel red pigment from marine Arthrobacter sp. G20 with specific anticancer activity. J Appl Microbiol 123(5):1228–1236. https://doi.org/10.1111/jam.13576 - DOI - PubMed
    1. Ali B, Sajjad W, Ghimire PS, Khan S, Din G, Kang S (2020a) Culture independent diversity of bacterial communities indigenous to lower altitude at Laohugou glacial environment. Geomicrobiology J 38(1):1–13. https://doi.org/10.1080/01490451.2020.1797946 - DOI
    1. Ali B, Sajjad W, Ghimire PS, Shengyun C, Minghui W, Kang S (2019) Culture-dependent diversity of bacteria from Laohugou glacier, Qilian Mts., China and their resistance against metal. J Basic Microbiol 59(11):1065–1081. https://doi.org/10.1002/jobm.201900385 - DOI - PubMed
    1. Ali B, Sajjad W, Khan I, Rafiq M, Zada S, Shah AA, Hasan F (2020b) Antibacterial activity and tolerance towards heavy metals by endolithic and epilithic bacteria isolated from rocks of Nathiagali, lower Himalaya, Pakistan. Pak J Zool 52(2):425–824. https://doi.org/10.17582/journal.pjz/20190128140128 - DOI
    1. Allen HK, Donato J, Wang HH, Cloud-Hansen KA, Davies J, Handelsman J (2010) Call of the wild: antibiotic resistance genes in natural environments. Nat Rev Microbiol 8(4):251–259. https://doi.org/10.1038/nrmicro2312 - DOI - PubMed

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