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Review
. 2024 May;108(3):553-566.
doi: 10.1016/j.mcna.2023.11.007. Epub 2023 Dec 18.

Medical Decision-Making and Revascularization in Ischemic Cardiomyopathy

Alex J Chang  1 , Yilin Liang  1 , Steven A Hamilton  2 , Andrew P Ambrosy  3
Affiliations
Review

Medical Decision-Making and Revascularization in Ischemic Cardiomyopathy

Alex J Chang et al. Med Clin North Am. 2024 May.

Abstract

Ischemic cardiomyopathy (ICM) is the most common underlying etiology of heart failure in the United States and is a significant contributor to deaths due to cardiovascular disease worldwide. The diagnosis and management of ICM has advanced significantly over the past few decades, and the evidence for medical therapy in ICM is both compelling and robust. This contrasts with evidence for coronary revascularization, which is more controversial and favors surgical approaches. This review will examine landmark clinical trial results in detail as well as provide a comprehensive overview of the current epidemiology, diagnostic approaches, and management strategies of ICM.

Keywords: Coronary artery bypass grafting; Coronary artery disease; Heart failure; Ischemic cardiomyopathy; Myocardial viability; Percutaneous coronary intervention; Revascularization.

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Conflict of interest statement

Disclosures Dr A.P. Ambrosy has received relevant research support through grants to his institution from the National Heart, Lung, and Blood Institute, United States (K23HL150159), the American Heart Association, United States (2nd Century Early Faculty Independence Award), The Permanente Medical Group, Northern California Community Health Program, Garfield Memorial Fund, Abbott Laboratories, Amarin Pharma, Inc., Edwards Lifesciences LLC, Esperion Therapeutics, Inc., and Novartis. All other authors have no relevant financial disclosures.