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. 2024 Mar 16:18:100646.
doi: 10.1016/j.ajpc.2024.100646. eCollection 2024 Jun.

Relationship between body mass index and cardiometabolic health in a multi-ethnic population: A project baseline health study

Nishant P Shah  1 , Rong Lu  2 , Francois Haddad  3 , Scarlet Shore  4 , Terry Schaack  5 , Jessica Mega  4 , Neha J Pagidipati  1 , Latha Palaniappan  6 , Kenneth Mahaffey  3 , Svati H Shah  7 , Fatima Rodriguez  6 ; Project Baseline Health Study Group
Affiliations

Relationship between body mass index and cardiometabolic health in a multi-ethnic population: A project baseline health study

Nishant P Shah et al. Am J Prev Cardiol. .

Abstract

Objective: Obesity is associated with a higher risk of cardiovascular disease. Understanding the associations between comprehensive health parameters and body mass index (BMI) may lead to targeted prevention efforts.

Methods: Project Baseline Health Study (PBHS) participants were divided into six BMI categories: underweight (BMI <18.5 kg/m2), normal weight (BMI 18.5-24.9 kg/m2), overweight (BMI 25-29.9 kg/m2), class I obesity (30-34.9 kg/m2), class II obesity (35-39.9 kg/m2), and class III obesity (BMI ≥40 kg/m2). Demographic, cardiometabolic, mental health, and physical health parameters were compared across BMI categories, and multivariable logistic regression models were fit to evaluate associations.

Results: A total of 2,493 PBHS participants were evaluated. The mean age was 50±17.2 years; 55 % were female, 12 % Hispanic, 16 % Black, and 10 % Asian. The average BMI was 28.4 kg/m2±6.9. The distribution of BMI by age group was comparable to the 2017-2018 National Health and Nutrition Examination Survey (NHANES) dataset. The obesity categories had higher proportions of participants with CAC scores >0, hypertension, diabetes, lower HDL-C, lower vitamin D, higher triglycerides, higher hsCRP, lower mean step counts, higher mean PHQ-9 scores, and higher mean GAD-7 scores.

Conclusion: We identified associations of cardiometabolic and mental health characteristics with BMI, thereby providing a deeper understanding of cardiovascular health across BMI.

Keywords: BMI; Obesity; Project baseline health study.

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Conflict of interest statement

The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: All authors acknowledge institutional research grants from Verily Life Sciences. NPS received research grants from Amgen, Janssen, and the National Institutes of Health (NIH) and served as a consultant/advisor for Esperion, Amgen, and Novartis. FH received an institutional research grant from Actelion Ltd. within the last 2 years and an institutional research grant from Precordior Ltd. KM reports grants from Verily, Afferent, the American Heart Association (AHA), Cardiva Medical Inc, Gilead, Luitpold, Medtronic, Merck, Eidos, Ferring, Apple Inc, Sanifit, and St. Jude; grants and personal fees from Amgen, AstraZeneca, Bayer, CSL Behring, Johnson & Johnson, Novartis, and Sanofi; and personal fees from Anthos, Applied Therapeutics, Elsevier, Inova, Intermountain Health, Medscape, Mount Sinai, Mundi Pharma, Myokardia, Novo Nordisk, Otsuka, Portola, SmartMedics, and Theravance outside the submitted work. The other authors have no conflicts of interest to disclose.

Figures

Image, graphical abstract
Graphical abstract
Fig. 1
Fig. 1
Panel A represents the percentage of participants across color-coded BMI categories (y axis) by age (x axis) in the PBHS cohort. Panel B represents the percentage of participants across color-coded BMI categories (y axis) by age (x axis) in the 2017–2018 NHANES cohort. BMI, body mass index; NHANES, National Health and Nutrition Examination Survey; PBHS, Project Baseline Health Study.
See this image and copyright information in PMC

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