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. 2024 Jun;36(25):e2401689.
doi: 10.1002/adma.202401689. Epub 2024 Apr 8.

Bioinspired Bottlebrush Polymers Effectively Alleviate Frictional Damage Both In Vitro and In Vivo

Duy Anh Pham  1 , Chang-Sheng Wang  1 , Line Séguy  1   2 , Hu Zhang  1 , Sabrina Benbabaali  3 , Jimmy Faivre  1 , Sotcheadt Sim  4 , Guojun Xie  5 , Mateusz Olszewski  5 , Jean-Michel Rabanel  1 , Florina Moldovan  2 , Krzysztof Matyjaszewski  5 , Xavier Banquy  1   6   7
Affiliations

Bioinspired Bottlebrush Polymers Effectively Alleviate Frictional Damage Both In Vitro and In Vivo

Duy Anh Pham et al. Adv Mater. 2024 Jun.

Abstract

Bottlebrush polymers (BB) have emerged as compelling candidates for biosystems to face tribological challenges, including friction and wear. This study provides a comprehensive assessment of an engineered triblock BB polymer's affinity, cell toxicity, lubrication, and wear protection in both in vitro and in vivo settings, focusing on applications for conditions like osteoarthritis and dry eye syndrome. Results show that the designed polymer rapidly adheres to various surfaces (e.g., cartilage, eye, and contact lens), forming a robust, biocompatible layer for surface lubrication and protection. The tribological performance and biocompatibility are further enhanced in the presence of hyaluronic acid (HA) both in vitro and in vivo. The exceptional lubrication performance and favorable interaction with HA position the synthesized triblock polymer as a promising candidate for innovative treatments addressing deficiencies in bio-lubricant systems.

Keywords: bio‐lubrication; bottlebrush; contact lens; dry eye; osteoarthritis.

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