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Review
. 2024 Sep;31(9):2560-2575.
doi: 10.1007/s43032-024-01520-z. Epub 2024 Mar 29.

Actively Targeted Nanomedicines: A New Perspective for the Treatment of Pregnancy-Related Diseases

Hui Yang  1 , Shan Wang  2
Affiliations
Review

Actively Targeted Nanomedicines: A New Perspective for the Treatment of Pregnancy-Related Diseases

Hui Yang et al. Reprod Sci. 2024 Sep.

Abstract

More than 20% of pregnant women experience serious complications during pregnancy, that gravely affect the safety of both the mother and the child. Due to the unique state of pregnancy, medication during pregnancy is subject to various restrictions. Nanotechnology is an emerging technology that has been the focus of extensive medical research, and great progress has recently been made in developing sensitive diagnostic modalities and efficient medical treatment. Accumulating evidence has shown that nanodrug delivery systems can significantly improve the targeting, reduce the toxicity and improve the bioavailability of drugs. Recently, some actively targeted nanomedicines have been explored in the treatment of pregnancy-related diseases. This article reviews common types of nanocarriers and active targeting ligands in common pregnancy-related diseases and complications such as preeclampsia, preterm birth, fetal growth restriction, and choriocarcinoma. Finally, the challenges and future prospects in the development of these nanomaterials are discussed, with the aim of providing guidance for future research directions.

Keywords: Actively targeted medicine; Nanomedicine; Nanoparticles; Placental targeted drugs; Pregnancy-related diseases; Uterine targeted drugs.

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