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Randomized Controlled Trial
. 2024 Mar 29;24(1):300.
doi: 10.1186/s12877-024-04876-8.

Iron status determined changes in health measures induced by nordic walking with time-restricted eating in older adults- a randomised trial

Jakub Antoni Kortas #  1 , Joanna Reczkowicz #  2 , Ulana Juhas  2 , Ewa Ziemann  3 , Aleksandra Świątczak  4 , Katarzyna Prusik  5 , Szczepan Olszewski  2 , Nakisa Soltani  2 , Ewa Rodziewicz-Flis  6 , Damian Flis  7 , Małgorzata Żychowska  8 , Grażyna Gałęzowska  2 , Jędrzej Antosiewicz  9
Affiliations
Randomized Controlled Trial

Iron status determined changes in health measures induced by nordic walking with time-restricted eating in older adults- a randomised trial

Jakub Antoni Kortas et al. BMC Geriatr. .

Abstract

Background and aims: This study evaluated whether stored iron determines the adaptive response induced by Nordic walking (NW) training combined with 10 hours' time-restricted eating (TRE) in older adults.

Trial design and methods: Twenty-four participants underwent 12-week NW training supported by 10 h of TRE. The group was divided due to baseline ferritin concentration low < 75 ng/ml (LF) and high level ≥ 75 ng/ml (HF). Body composition, physical fitness and blood collection were assessed at baseline and post-intervention.

Results: NW + TRE induced a statistically significant decrease in ferritin levels in all participants (p = 0.01). Additionally, statistically significant intergroup differences in the LF vs. HF in the reduction of serum ferritin levels (p = 0.04) were observed. The procedure NW + TRE diminished HbA1c levels (p < 0.01) and glucose in all participants (p = 0.05). The range of HbA1c drop was more pronounced among those participants who experienced a greater decrease in the stored iron (p = 0.04, [Formula: see text]=0.17, F=4.59). Greater changes in body weight and percent of body fat were recorded in the HF group (for both p<0.01).

Conclusion: Body iron stores determine the effects of a 12-week NW + TRE intervention on serum ferritin. The changes in HbA1c are more pronounced in subjects with a higher decrease in serum ferritin.

Trial registration: All experimental protocols were approved by the Bioethical Committee of the Regional Medical Society in Gdansk, Poland (NKBBN/330/2021) according to the Declaration of Helsinki. We confirm that all methods were carried out in accordance with relevant guidelines and regulations. The trial was registered as a clinical trial (NCT05229835, date of first registration: 14/01/2022, direct link: https://classic.

Clinicaltrials: gov/ct2/show/NCT05229835 ). Informed consent was obtained from all subjects.

Keywords: Body iron; Ferritin; HbA1c; Serum glucose; Soluble transferrin receptor.

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Conflict of interest statement

The authors declare that the research was conducted without any commercial or financial relationships that could be construed as a potential conflict of interest.

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flow diagram of the study
Fig. 2
Fig. 2
Overview of the participants’ activity during the NW + TRE intervention
Fig. 3
Fig. 3
Effects of NW + TRE on HbA1c in subgroups with different changes in serum (by repeated-measures analyses of variance with post-hoc tests,formula image– the effect size, F– value in repeated measures ANOVA * p < 0.05). The group where ferritin decreased by more than 20ng/ml (n = 9) and less than 20ng/ml (n = 15)
Fig. 4
Fig. 4
Beneficial effects of time-restricted eating (TRE) combined with Nordic Walking training (NW) are related to baseline ferritin concentration. During 12 weeks of NW + TRE, changes in ferritin, body weight, skeletal muscle mass, and fat mass were significantly higher in participants with baseline ferritin above 75 ng/ml (HF) compared to those with ferritin lower than 75 ng/ml (LF). The changes in blood glucose and HbA1c were similar in both groups (↓) -indicates that changes were significant after the intervention in all subjects, (↓↓ or ↑↑)- Indicates that the changes significantly differed from those observed in participants with serum ferritin lower than 75 ng/ml. Created with BioRender.com
See this image and copyright information in PMC

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