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Meta-Analysis
. 2024 Mar 30;19(1):162.
doi: 10.1186/s13019-024-02654-6.

Double lung transplantation is better than single lung transplantation for end-stage chronic obstructive pulmonary disease: a meta-analysis

Yu-Chi Fang #  1 , Wen-Hsin Cheng #  1 , Hung-I Lu  1 , Yi-Shi Wang  2 , Kai-Hao Chuang  1 , Hsing-Hua Lai  1 , Yu Chen  1 , Li-Chun Chen  1 , Meng-Yun Tsai  2 , Yu-Ping Chang  2 , Kuo-Tung Huang  2 , Chien-Ming Lo  3
Affiliations
Meta-Analysis

Double lung transplantation is better than single lung transplantation for end-stage chronic obstructive pulmonary disease: a meta-analysis

Yu-Chi Fang et al. J Cardiothorac Surg. .

Abstract

Background: Lung transplantation is one of the most common treatment options for patients with end-stage chronic obstructive pulmonary disease. However, the choice between single and double lung transplantation for these patients remains a matter of debate. Therefore, we performed a systematic search of medical databases for studies on single lung transplantation, double lung transplantation, and chronic obstructive pulmonary disease.

Methods: The rate ratio and hazard ratio of survival were analyzed. The meta-analysis included 15 case-control and retrospective registry studies.

Results: The rate ratios of the 3-year survival (0.937 and P = 0.041) and 5-year survival (0.775 and P = 0.000) were lower for single lung transplantation than for double lung transplantation. However, the hazard ratio did not differ significantly between the two.

Conclusions: Double lung transplantation was found to provide better benefits than single lung transplantation in terms of the long-term survival in patients with chronic obstructive pulmonary disease.

Keywords: Chronic obstructive; Lung transplantation; Meta-analysis; Proportional hazards models; Pulmonary disease; Registries; Survival.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Preferred reporting items for systematic reviews and meta-analyses (PRISMA) flow diagram
Fig. 2
Fig. 2
Rate ratio analysis of 1-year survival following double and single lung transplantation. CI, confidence interval; DLT, double lung transplantation; SLT, single lung transplantation
Fig. 3
Fig. 3
Rate ratio analysis of 3-year survival following double and single lung transplantation. CI, confidence interval; DLT, double lung transplantation; SLT, single lung transplantation
Fig. 4
Fig. 4
Rate ratio analysis of 5-year survival following double and single lung transplantation. CI, confidence interval; DLT, double lung transplantation; SLT, single lung transplantation
Fig. 5
Fig. 5
Hazard ratio analysis of double and single lung transplantation. a Without propensity score matching in the study by Thabut et al. b With propensity score matching. CI, confidence interval; DLT, double lung transplantation; SLT, single lung transplantation
Fig. 6
Fig. 6
Funnel plot of all studies that included 1-year survival data
Fig. 7
Fig. 7
Funnel plot of all studies that included 3-year survival data
Fig. 8
Fig. 8
Funnel plot of all studies that included 5-year survival data
Fig. 9
Fig. 9
Funnel plot of all studies included in the hazard ratio analysis. a Without propensity score matching in the study by Thabut et al. b With propensity score matching
See this image and copyright information in PMC

References

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