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. 1985 Mar;51(3):389-92.
doi: 10.1038/bjc.1985.52.

HLA and nasopharyngeal carcinoma in Malays

S H Chan, C T Chew, U Prasad, G B Wee, N Srinivasan, N Kunaratnam
Free PMC article

HLA and nasopharyngeal carcinoma in Malays

S H Chan et al. Br J Cancer. 1985 Mar.
Free PMC article

Abstract

HLA associations were observed in unrelated Malay patients with nasopharyngeal carcinoma (NPC). HLA-B18 was observed in 18/45 (40%) Malay NPC patients compared to 22/167 (13%) Malay normals (P = 0.0001; Pc = 0.0027, RR = 4.4). The frequency of HLA-B17, one of the antigens associated with Chinese NPC, was also increased among Malay NPC (13/45 29%) compared to controls (18/167 11%; P = 0.003, Pc = 0.07 RR = 3.4). Similar to the findings among Chinese NPC, the frequency of B17 was higher in early onset (less than or equal to 30 years) Malay NPC resulting in a higher relative risk (RR = 5.0).

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