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Review
. 2024 Apr;30(4):e13665.
doi: 10.1111/srt.13665.

Advances in stem cells treatment of diabetic wounds: A bibliometric analysis via CiteSpace

Ke Ma  1   2   3 , Chao Luo  4 , Mindong Du  2   5 , Qiang Wei  1 , Qianxuan Luo  1 , Li Zheng  2   3 , Mingde Liao  1
Affiliations
Review

Advances in stem cells treatment of diabetic wounds: A bibliometric analysis via CiteSpace

Ke Ma et al. Skin Res Technol. 2024 Apr.

Abstract

Diabetes is a chronic medical condition that may induce complications such as poor wound healing. Stem cell therapies have shown promise in treating diabetic wounds with pre-clinical and clinical studies. However, little bibliometric analysis has been carried out on stem cells in the treatment of diabetic wounds. In this study, we retrieved relevant papers published from January 1, 2003, to December 31, 2023, from Chinese and English databases. CiteSpace software was used to analyze the authors, institutions, and keywords by standard bibliometric indicators. Our analysis findings indicated that publications on stem cells in the treatment of diabetic wounds kept increasing. The most prolific author was Qian Cai (n = 7) and Mohammad Bayat (n = 16) in Chinese and English databases, respectively. Institutions distribution analysis showed that Chinese institutions conducted most publications, and the most prolific institution was the Chinese People's Liberation Army General Hospital (n = 9) and Shahid Beheshti University of Medical Sciences (n = 17) in Chinese and English databases, respectively. The highest centrality keyword in Chinese and English databases was "wound healing" (0.54) and "in vitro" (0.13), respectively. There were 8 and 11 efficient and convincing keyword clusters produced by a log-likelihood ratio in the Chinese and English databases, respectively. The strongest burst keyword was "exosome" (strength 3.57) and "endothelial progenitor cells" (strength 7.87) in the Chinese and English databases, respectively. These findings indicated a direction for future therapies and research on stem cells in the treatment of diabetic wounds.

Keywords: CiteSpace; bibliometric analysis; diabetic wound; stem cells.

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Conflict of interest statement

The authors declare that there is no conflict of interest regarding the publication of this paper.

Figures

FIGURE 1
FIGURE 1
The number of publications on stem cell in the treatment of diabetic wounds from 2003 to 2023.
FIGURE 2
FIGURE 2
Bibliometric analysis of the authors of publications from the Chinese (A) and English (B) databases.
FIGURE 3
FIGURE 3
Bibliometric analysis of the institutions of publications from the Chinese (A) and English (B) databases.
FIGURE 4
FIGURE 4
The keyword clusters produced from the Chinese (A) and English (B) databases.
FIGURE 5
FIGURE 5
Bibliometric analysis of the keywords of publications from the Chinese (A) and English (B) databases.
FIGURE 6
FIGURE 6
Top 10 keywords with the strongest citation bursts from the Chinese (A) and English (B) databases.
See this image and copyright information in PMC

References

    1. IDF Atlas‐10th edition. 2021. www. diabetesatlas.org. Accessed April 12, 2023
    1. Zheng Y, Ley SH, Hu FB. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol. 2018;14(2):88–98. doi:10.1038/nrendo.2017.151 - DOI - PubMed
    1. Cole JB, Florez JC. Genetics of diabetes mellitus and diabetes complications. Nat Rev Nephrol. 2020;16(7):377–390. doi:10.1038/s41581-020-0278-5 - DOI - PMC - PubMed
    1. Chang M, Nguyen TT. Strategy for treatment of infected diabetic foot ulcers. Accounts Chem Res. 2021;54(5):1080–1093. doi:10.1021/acs.accounts.0c00864 - DOI - PubMed
    1. Matoori S, Veves A, Mooney DJ. Advanced bandages for diabetic wound healing. Sci Transl Med. 2021;13(585):eabe4839. doi:10.1126/scitranslmed.abe4839 - DOI - PubMed

Supplementary concepts