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Case Reports
. 1979 Nov;40(11):483-5.

Sodium valproate in tardive dyskinesia

D E Casey, J P Hammerstad
  • PMID: 385585
Case Reports

Sodium valproate in tardive dyskinesia

D E Casey et al. J Clin Psychiatry. 1979 Nov.

Abstract

Recent findings suggest that tardive dyskinesia may involve GABA-ergic influences in addition to dopaminergic receptor hypersensitivity and relative cholinergic hypofunction. Sodium valproate, which may increase brain GABA, moderately recuded tardive dyskinesia with doses of 900--3000 mg/day, as measured by a tremorgraph and rating scales. There was no correlation between dosage, blood levels, or clinical response. Although the symptoms were not completely controlled, valproate and other GABA-ergic agents may be useful compounds in studying and treating tardive dyskinesia.

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