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Review
. 2024 Mar 28:15:20406207241237602.
doi: 10.1177/20406207241237602. eCollection 2024.

Research advances on short-chain fatty acids in gastrointestinal acute graft- versus-host disease

Xinping Song  1 , Jing Lao  1 , Lulu Wang  2 , Sixi Liu  2
Affiliations
Review

Research advances on short-chain fatty acids in gastrointestinal acute graft- versus-host disease

Xinping Song et al. Ther Adv Hematol. .

Abstract

Gastrointestinal acute graft-versus-host disease (GI-aGVHD) is a severe early complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT). It has been shown that the intestinal microbiota plays a critical role in this process. As metabolites of the intestinal microbiota, short-chain fatty acids (SCFAs) are vital for maintaining the host-microbiota symbiotic equilibrium. This article provides an overview of the protective effect of SCFAs in the gastrointestinal tract, emphasizes their association with GI-aGVHD, and explores relevant research progress in prevention and treatment research.

Keywords: acute graft-versus-host disease; allogeneic hematopoietic stem-cell transplantation; short-chain fatty acids.

Plain language summary

Research advances on short-chain fatty acids in gastrointestinal acute graft-versus-host disease Gastrointestinal acute graft-versus-host disease (GI-aGVHD) is a severe early complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT). It has been shown that the intestinal microbiota plays a critical role in this process. As metabolites of the intestinal microbiota, short-chain fatty acids (SCFAs) are vital for maintaining the host-microbiota symbiotic equilibrium. This article provides an overview of the protective effect of SCFAs in the gastrointestinal tract, emphasizes their association with GI-aGVHD and explores relevant research progress in prevention and treatment research.

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Conflict of interest statement

The authors declare that there is no conflict of interest.

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