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. 2022 Sep 28:22:100212.
doi: 10.1016/j.ahjo.2022.100212. eCollection 2022 Oct.

Association between high-sensitivity cardiac troponin T levels and incident stroke in the elderly Japanese population: Results from the Tohoku Medical Megabank Community-based Cohort Study

Takamasa Kobayashi  1 , Takahito Nasu  1   2   3 , Mamoru Satoh  2   3 , Yuka Kotozaki  3 , Kozo Tanno  3   4 , Koichi Asahi  3   5 , Hideki Ohmomo  2   3 , Atsushi Shimizu  2   3 , Shinichi Omama  6 , Hiroto Kikuchi  1   2 , Satoru Taguchi  1   2 , Yoshihiro Morino  2 , Kenji Sobue  7 , Makoto Sasaki  3   8
Affiliations

Association between high-sensitivity cardiac troponin T levels and incident stroke in the elderly Japanese population: Results from the Tohoku Medical Megabank Community-based Cohort Study

Takamasa Kobayashi et al. Am Heart J Plus. .

Abstract

Elevated levels of circulating high-sensitivity cardiac troponin T (hs-cTnT) are associated with cardiovascular disease. This study aimed to examine whether hs-cTnT levels are associated with incident stroke in the elderly population. The Iwate Tohoku Medical Megabank Organization pooled participant data for a community-based cohort study (n = 15,063, 69.6 ± 3.4 years), with a mean follow-up period of 5.23 years for all-cause death and incident stroke. The follow-up revealed 316 incident strokes, including atherothrombotic (n = 98), cardioembolic (n = 54), lacunar (n = 63), hemorrhagic (n = 101), and 178 all-cause deaths. Participants were classified into quartiles according to hs-cTnT levels (Q1 ≦ 4 ng/L, Q2: 5-6 ng/L, Q3: 7-9 ng/L, and Q4 > 9 ng/L). After adjusting for sex, age, smoking, drinking, systolic blood pressure, estimated glomerular filtration rate, N-terminal pro-brain natriuretic peptide, hemoglobin A1c, and lipid profile, a Cox proportional hazard model showed that higher hs-cTnT levels were associated with ischemic stroke (Q1 vs. Q4, hazard ratio [HR] = 2.24, 95 % confidence interval [CI] = 1.12-4.51, p = 0.023). The incident of total stroke was not associated with hs-cTnT levels (Q1 vs. Q4, HR 1.39, 95 % CI = 0.89-1.74, p = 0.145). Numerical differences were highest regarding incident lacunar stroke subtypes; however, this association was not statistically significant. Higher hs-cTnT concentrations were associated with ischemic stroke in the elderly Japanese population.

Keywords: Biomarker; Cerebrovascular disease; Follow-up study; Ischemic stroke.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Distribution map of hs-cTnT levels. Hs-cTnT, high-sensitivity cardiac troponin T.
Fig. 2
Fig. 2
Kaplan–Meier survival and event-time curve according to hs-cTnT levels. (A) All-cause death, (B) total stroke, (C) intracerebral stroke, and (D) ischemic stroke-free probability based on quartiles according to hs-cTnT levels (Q1 ≦ 4 ng/L, Q2: 5–6 ng/L, Q3: 7–9 ng/L, and Q4 > 9 ng/L). Hs-cTnT, high-sensitivity cardiac troponin.
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References

    1. Matsui H., Fushimi K., Yasunaga H. Variation in risk-standardized mortality of stroke among hospitals in Japan. PLoS One. 2015;10 - PMC - PubMed
    1. Caprio F.Z., Sorond F.A. Cerebrovascular disease: primary and secondary stroke prevention. Med. Clin. N. Am. 2019;103:295–308. - PubMed
    1. Yatsuya H., Iso H., Yamagishi K., et al. Development of a point-based prediction model for the incidence of total stroke: Japan public health center study. Stroke. 2013;44:1295–1302. - PubMed
    1. Lindahl B., Venge P., Wallentin L. Relation between troponin T and the risk of subsequent cardiac events in unstable coronary artery disease. The FRISC study group. Circulation. 1996;93:1651–1657. - PubMed
    1. Giannitsis E., Kurz K., Hallermayer K., et al. Analytical validation of a high-sensitivity cardiac troponin T assay. Clin. Chem. 2010;56:254–261. - PubMed