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Editorial
. 2024 Mar 28;9(3):396-398.
doi: 10.1016/j.jacbts.2024.01.004. eCollection 2024 Mar.

A Valuable Genetically Engineered Nonhuman Primate Model of Dilated Cardiomyopathy

Toshiyuki Ko  1 , Issei Komuro  2   3
Affiliations
Editorial

A Valuable Genetically Engineered Nonhuman Primate Model of Dilated Cardiomyopathy

Toshiyuki Ko et al. JACC Basic Transl Sci. .
No abstract available

Keywords: CRISPR-mediated adenine base editing; dilated cardiomyopathy; lamin A and C; primate model.

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Conflict of interest statement

Dr Ko was supported by grants from the Japan Foundation for Applied Enzymology, the MSD Life Science Foundation, the Sakakibara Heart Foundation Cardiovascular Research Program 2023, the Japanese Circulation Society, the Takeda Science Foundation, the Japan Heart Foundation, and AMED (JP23ek0109600h0002). Dr Komuro has reported that he has no relationships relevant to the contents of this paper to disclose.

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Graphical abstract
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Comment on

  • doi: 10.1016/j.jacbts.2023.11.002

References

    1. Fatkin D., Huttner I.G., Kovacic J.C., Seidman J.G., Seidman C.E. Precision medicine in the management of dilated cardiomyopathy: JACC state-of-the-art review. J Am Coll Cardiol. 2019;74(23):2921–2938. doi: 10.1016/j.jacc.2019.10.011. - DOI - PubMed
    1. Yamada T., Ko T., Ito M., et al. TEAD1 trapping by the Q353R-lamin A/C causes dilated cardiomyopathy. Sci Adv. 2023;9(15) - PMC - PubMed
    1. Luo X., Jia H., Wang F., et al. Primate model carrying LMNA mutation develops dilated cardiomyopathy. J Am Coll Cardiol Basic Trans Science. 2024;9(3):380–395. - PMC - PubMed
    1. Feng G., Jensen F.E., Greely H.T., et al. Opportunities and limitations of genetically modified nonhuman primate models for neuroscience research. Proc Natl Acad Sci U S A. 2020;117(39):24022–24031. - PMC - PubMed
    1. Wang F., Zhang W., Yang Q., et al. Generation of a Hutchinson-Gilford progeria syndrome monkey model by base editing. Protein Cell. 2020;11:809–824. - PMC - PubMed

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