Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2024 Mar 28;9(3):319-321.
doi: 10.1016/j.jacbts.2024.01.016. eCollection 2024 Mar.

Mitochondrial Targeted Therapies to Prevent Maternal Diabetes-Induced Congenital Heart Defects

Sushma Reddy  1
Affiliations
Editorial

Mitochondrial Targeted Therapies to Prevent Maternal Diabetes-Induced Congenital Heart Defects

Sushma Reddy. JACC Basic Transl Sci. .
No abstract available

Keywords: congenital heart defects; fusion; maternal diabetes; mitochondria.

PubMed Disclaimer

Conflict of interest statement

Dr Reddy is supported by an Additional Ventures Foundation grant, a Maternal Child Health Research Institute Faculty Scholar Award, and National Heart, Lung, and Blood Institute grant 1 R01 HL165245.

Figures

None
Graphical abstract
See this image and copyright information in PMC

Comment on

  • doi: 10.1016/j.jacbts.2023.11.008

Similar articles

See all similar articles

References

    1. Lopez K.N., Morris S.A., Tejtel S.K.S., Espaillat A., Salemi J.L. US mortality attributable to congenital heart disease across the lifespan from 1999 through 2017 exposes persistent racial/ethnic disparities. Circulation. 2020;142:1132–1147. - PMC - PubMed
    1. Ibrahim S., Gaborit B., Lenoir M., Collod-Beroud G., Stefanovic S. Maternal pre-existing diabetes: a non-inherited risk factor for congenital cardiopathies. Int J Mol Sci. 2023;24(22) doi: 10.3390/ijms242216258. - DOI - PMC - PubMed
    1. Øyen N., Diaz L.J., Boyd H.A., Pr, et al. Prepregnancy diabetes and offspring risk of congenital heart disease: a nationwide cohort study. Circulation. 2016;133:2243–2253. - PMC - PubMed
    1. Liu X., Guo C., Zhang Q. Novel insights into the involvement of mitochondrial fission/fusion in heart failure: from molecular mechanisms to targeted therapies. Cell Stress Chaperones. 2023;28(2):133–144. - PMC - PubMed
    1. Wang G., Lu W., Shen W.-B., Karbowski M., Kaushal S., Yang P. Small molecule activators of mitochondrial fusion prevent congenital heart defects induced by maternal diabetes. J Am Coll Cardiol Basic Trans Science. 2024;9(3):303–318. - PMC - PubMed

Publication types

LinkOut - more resources