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Editorial
. 2024 Mar 28;9(3):319-321.
doi: 10.1016/j.jacbts.2024.01.016. eCollection 2024 Mar.

Mitochondrial Targeted Therapies to Prevent Maternal Diabetes-Induced Congenital Heart Defects

Sushma Reddy  1
Affiliations
Editorial

Mitochondrial Targeted Therapies to Prevent Maternal Diabetes-Induced Congenital Heart Defects

Sushma Reddy. JACC Basic Transl Sci. .
No abstract available

Keywords: congenital heart defects; fusion; maternal diabetes; mitochondria.

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Conflict of interest statement

Dr Reddy is supported by an Additional Ventures Foundation grant, a Maternal Child Health Research Institute Faculty Scholar Award, and National Heart, Lung, and Blood Institute grant 1 R01 HL165245.

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Graphical abstract
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Comment on

References

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    1. Ibrahim S., Gaborit B., Lenoir M., Collod-Beroud G., Stefanovic S. Maternal pre-existing diabetes: a non-inherited risk factor for congenital cardiopathies. Int J Mol Sci. 2023;24(22) doi: 10.3390/ijms242216258. - DOI - PMC - PubMed
    1. Øyen N., Diaz L.J., Boyd H.A., Pr, et al. Prepregnancy diabetes and offspring risk of congenital heart disease: a nationwide cohort study. Circulation. 2016;133:2243–2253. - PMC - PubMed
    1. Liu X., Guo C., Zhang Q. Novel insights into the involvement of mitochondrial fission/fusion in heart failure: from molecular mechanisms to targeted therapies. Cell Stress Chaperones. 2023;28(2):133–144. - PMC - PubMed
    1. Wang G., Lu W., Shen W.-B., Karbowski M., Kaushal S., Yang P. Small molecule activators of mitochondrial fusion prevent congenital heart defects induced by maternal diabetes. J Am Coll Cardiol Basic Trans Science. 2024;9(3):303–318. - PMC - PubMed

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