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. 2022 Nov 24:24:100230.
doi: 10.1016/j.ahjo.2022.100230. eCollection 2022 Dec.

Ten year real world experience with ultrafiltration for the management of acute decompensated heart failure

Donald C Haas  1 , Maureen Hummel  1 , Patricia Barrella  1 , Waqas Ullah  2 , Misung Yi  3 , Robert A Watson 3rd  1
Affiliations

Ten year real world experience with ultrafiltration for the management of acute decompensated heart failure

Donald C Haas et al. Am Heart J Plus. .

Abstract

Background: Randomized controlled trials (RCT) of ultrafiltration (UF) have demonstrated conflicting results regarding its efficacy and safety.

Objective: We reviewed 10 years of data for adjustable UF during heart failure hospitalizations in a real world cohort.

Methods: We performed a retrospective, single center analysis of 335 consecutive patients treated with adjustable rate UF using the CHF Solutions Aquadex Flex Flo System from 2009 to 2019.

Results: Compared to previous RCTs investigating UF, our cohort was older, with worse renal impairment and more antecedent HF hospitalizations in the year preceding therapy. Mean fluid removal with UF was 14.6 l. Mean weight loss with UF was 15.6 lbs (range 0.2-57 lbs) and was sustained at 1-2 week follow-up. Mean creatinine change upon stopping UF, at discharge and follow-up (mean 30 days) was +0.11 mg/dl, +0.07 mg/dl and +0.11 mg/dl, respectively. HF rehospitalizations at 30 days, 90 days and 1 year were 12.4 %, 14.9 % and 27.3 % respectively. On average patients had 1.74 fewer hospitalizations for HF in the year following UF when compared to 12 months preceding UF. Major bleeding defined as requiring discontinuation of anticoagulation occurred in 3.6 % of patients.

Conclusions: Compared with previous UF trials, our study demonstrates that UF compares favorably for HF rehospitalizations, renal function response, and weight/volume loss. Importantly, our real world experience allowed for the adjustment of UF rate during therapy and we believe this is a major contributor to our favorable outcomes. In clinical practice, UF can be a safe and effective strategy for decongestion.

Keywords: Aquapheresis; Decongestion; Heart failure; Ultrafiltration.

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Conflict of interest statement

The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Maureen Hummel reports financial support was provided by CHF Solutions (Nuwellis) for independent data analysis. Maureen Hummel reports a relationship with CHF Solutions (Nuwellis) that includes: speaking and lecture fees and travel reimbursement.

Figures

Fig. 1
Fig. 1
Range, mean, median and interquartile range of changes in blood urea nitrogen with UF at different time intervals with UF. ADM-admission; BUN-blood urea nitrogen; UF-ultrafiltration; DC-discharge; FU-follow up.
Fig. 2
Fig. 2
Range, mean, median and interquartile range of changes in serum creatinine level with UF at different time intervals with UF. ADM-admission; BUN-blood urea nitrogen; UF-ultrafiltration; DC-discharge; FU-follow up.
See this image and copyright information in PMC

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