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. 1985 Mar;314(6006):67-73.
doi: 10.1038/314067a0.

Hypervariable 'minisatellite' regions in human DNA

A J Jeffreys, V Wilson, S L Thein

Hypervariable 'minisatellite' regions in human DNA

A J Jeffreys et al. Nature. 1985 Mar.

Abstract

The human genome contains many dispersed tandem-repetitive 'minisatellite' regions detected via a shared 10-15-base pair 'core' sequence similar to the generalized recombination signal (chi) of Escherichia coli. Many minisatellites are highly polymorphic due to allelic variation in repeat copy number in the minisatellite. A probe based on a tandem-repeat of the core sequence can detect many highly variable loci simultaneously and can provide an individual-specific DNA 'fingerprint' of general use in human genetic analysis.

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