Insulin-like growth factor-1 and insulin-like growth factor binding protein-3 as early predictors of growth, body composition, and neurodevelopment in preterm infants

doi:10.1038/s41372-024-01933-3

. 2024 Nov;44(11):1617-1623.

doi: 10.1038/s41372-024-01933-3. Epub 2024 Apr 1.

Insulin-like growth factor-1 and insulin-like growth factor binding protein-3 as early predictors of growth, body composition, and neurodevelopment in preterm infants

Megan E Paulsen^{1

2

3}, Nicholas Marka⁴, Scott Lunos⁴, Emily M Nagel⁵, Juan David Gonzalez Villamizar^{6

7}, Brandon Nathan⁸, Sara Ramel^{6

9}

Affiliations

¹ Division of Neonatology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA. megan.paulsen@childrensmn.org.
² Children's Minnesota, Minneapolis, MN, USA. megan.paulsen@childrensmn.org.
³ Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA. megan.paulsen@childrensmn.org.
⁴ Biostatistical Design and Analysis Center, Clinical Translational Science Institute, University of Minnesota, Minneapolis, MN, USA.
⁵ University of Minnesota School of Public Health, Minneapolis, MN, USA.
⁶ Division of Neonatology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.
⁷ Children's Minnesota, Minneapolis, MN, USA.
⁸ Division of Endocrinology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.
⁹ Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA.

PMID: 38561392
PMCID: PMC11442679 (available on 2025-11-01)
DOI: 10.1038/s41372-024-01933-3

Insulin-like growth factor-1 and insulin-like growth factor binding protein-3 as early predictors of growth, body composition, and neurodevelopment in preterm infants

Megan E Paulsen et al. J Perinatol. 2024 Nov.

. 2024 Nov;44(11):1617-1623.

doi: 10.1038/s41372-024-01933-3. Epub 2024 Apr 1.

Authors

Megan E Paulsen^{1

2

3}, Nicholas Marka⁴, Scott Lunos⁴, Emily M Nagel⁵, Juan David Gonzalez Villamizar^{6

7}, Brandon Nathan⁸, Sara Ramel^{6

9}

Affiliations

¹ Division of Neonatology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA. megan.paulsen@childrensmn.org.
² Children's Minnesota, Minneapolis, MN, USA. megan.paulsen@childrensmn.org.
³ Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA. megan.paulsen@childrensmn.org.
⁴ Biostatistical Design and Analysis Center, Clinical Translational Science Institute, University of Minnesota, Minneapolis, MN, USA.
⁵ University of Minnesota School of Public Health, Minneapolis, MN, USA.
⁶ Division of Neonatology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.
⁷ Children's Minnesota, Minneapolis, MN, USA.
⁸ Division of Endocrinology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.
⁹ Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA.

PMID: 38561392
PMCID: PMC11442679 (available on 2025-11-01)
DOI: 10.1038/s41372-024-01933-3

Abstract

Objective: To investigate the relationship between insulin-like growth factor 1 (IGF-1), insulin-like growth factor binding protein 3 (IGFBP-3) and long-term growth, body composition, and neurodevelopment in preterm infants.

Study design: Prospective data were collected from ≤32 weeks gestational age infant cohort (N = 50). IGF-1 and IGFBP-3 concentrations were measured at 1 week (early) and 35 weeks (late) post-menstrual age (PMA). Growth, body composition, and neurodevelopment outcomes were measured at 4 and 12 months PMA. Relationships were measured by linear regression analysis.

Results: Early IGFBP-3 concentration was positively associated with neurodevelopment at 12 months PMA. Early IGF-1 concentration was positively associated with weight at 4 months PMA, head circumference at 12 months PMA, and body mass index at 12 months PMA. Late IGFBP-3 concentration was positively associated with weight at 4 months PMA.

Conclusion: Further investigation of these associations may lead to novel biomarkers and/or treatments to optimize health outcomes in preterm infants.

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Conflict of interest statement

COMPETING INTERESTS

The authors declare no competing interests.

References

1. Geng T, Wang M, Li X, Zhou T, Ma H, Fonseca VA, et al. Birth weight modifies the relation between adulthood levels of insulin-like growth factor-1 and type 2 diabetes: a prospective cohort study. BMJ Open Diabetes Res Care. 2021;9:e001885. - PMC - PubMed
1. Hellstrom A, Ley D, Hansen-Pupp I, Hallberg B, Lofqvist C, van Marter L, et al. Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development. Acta Paediatr. 2016;105:576–86. - PMC - PubMed
1. Hellstrom A, Sigurdsson J, Lofqvist C, Hellgren G, Kistner A. The IGF system and longitudinal growth in preterm infants in relation to gestational age, birth weight and gender. Growth Horm IGF Res. 2020;51:46–57. - PubMed
1. Hellstrom W, Hortensius LM, Lofqvist C, Hellgren G, Tataranno ML, Ley D, et al. Postnatal serum IGF-1 levels associate with brain volumes at term in extremely preterm infants. Pediatr Res. 2022;93:666–74. - PMC - PubMed
1. Gonzalez Villamizar JD, Haapala JL, Scheurer JM, Rao R, Ramel SE. Relationships between Early Nutrition, Illness, and Later Outcomes among Infants Born Preterm with Hyperglycemia. J Pediatr. 2020;223:29–33.e2. - PubMed

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[1] Geng T, Wang M, Li X, Zhou T, Ma H, Fonseca VA, et al. Birth weight modifies the relation between adulthood levels of insulin-like growth factor-1 and type 2 diabetes: a prospective cohort study. BMJ Open Diabetes Res Care. 2021;9:e001885. - PMC - PubMed

[2] Geng T, Wang M, Li X, Zhou T, Ma H, Fonseca VA, et al. Birth weight modifies the relation between adulthood levels of insulin-like growth factor-1 and type 2 diabetes: a prospective cohort study. BMJ Open Diabetes Res Care. 2021;9:e001885. - PMC - PubMed

[3] Hellstrom A, Ley D, Hansen-Pupp I, Hallberg B, Lofqvist C, van Marter L, et al. Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development. Acta Paediatr. 2016;105:576–86. - PMC - PubMed

[4] Hellstrom A, Ley D, Hansen-Pupp I, Hallberg B, Lofqvist C, van Marter L, et al. Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development. Acta Paediatr. 2016;105:576–86. - PMC - PubMed

[5] Hellstrom A, Sigurdsson J, Lofqvist C, Hellgren G, Kistner A. The IGF system and longitudinal growth in preterm infants in relation to gestational age, birth weight and gender. Growth Horm IGF Res. 2020;51:46–57. - PubMed

[6] Hellstrom A, Sigurdsson J, Lofqvist C, Hellgren G, Kistner A. The IGF system and longitudinal growth in preterm infants in relation to gestational age, birth weight and gender. Growth Horm IGF Res. 2020;51:46–57. - PubMed

[7] Hellstrom W, Hortensius LM, Lofqvist C, Hellgren G, Tataranno ML, Ley D, et al. Postnatal serum IGF-1 levels associate with brain volumes at term in extremely preterm infants. Pediatr Res. 2022;93:666–74. - PMC - PubMed

[8] Hellstrom W, Hortensius LM, Lofqvist C, Hellgren G, Tataranno ML, Ley D, et al. Postnatal serum IGF-1 levels associate with brain volumes at term in extremely preterm infants. Pediatr Res. 2022;93:666–74. - PMC - PubMed

[9] Gonzalez Villamizar JD, Haapala JL, Scheurer JM, Rao R, Ramel SE. Relationships between Early Nutrition, Illness, and Later Outcomes among Infants Born Preterm with Hyperglycemia. J Pediatr. 2020;223:29–33.e2. - PubMed

[10] Gonzalez Villamizar JD, Haapala JL, Scheurer JM, Rao R, Ramel SE. Relationships between Early Nutrition, Illness, and Later Outcomes among Infants Born Preterm with Hyperglycemia. J Pediatr. 2020;223:29–33.e2. - PubMed

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Insulin-like growth factor-1 and insulin-like growth factor binding protein-3 as early predictors of growth, body composition, and neurodevelopment in preterm infants

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Insulin-like growth factor-1 and insulin-like growth factor binding protein-3 as early predictors of growth, body composition, and neurodevelopment in preterm infants

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