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Meta-Analysis
. 2025;32(20):4078-4094.
doi: 10.2174/0109298673260515240322074849.

The Effects of Curcumin Plus Piperine Co-administration on Inflammation and Oxidative Stress: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Hossein Hosseini  1 , Farideh Ghavidel  1 , Arezoo Rajabian  2 , Masoud Homayouni-Tabrizi  3 , Muhammed Majeed  4   5 , Amirhossein Sahebkar  6   7
Affiliations
Meta-Analysis

The Effects of Curcumin Plus Piperine Co-administration on Inflammation and Oxidative Stress: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Hossein Hosseini et al. Curr Med Chem. 2025.

Abstract

Background: The beneficial effects of curcumin against various chronic disorders have been shown in the last few decades. However, due to its low bioavailability, therapeutic effects are less than expected. Piperine has been used in scientific evaluations as an effective compound to increase the bioavailability of curcumin. The present review investigated the impact of curcumin plus piperine intake on oxidative stress and inflammatory markers of Randomized Clinical Trials (RCTs).

Methods: Using relevant keywords, we searched Cochrane Library, Scopus, PubMed, and Web of Science between January 1st, 1970, and September 30th, 2022. A comprehensive search for RCTs was performed. Continuous data were pooled by Standard Mean Difference (SMD) and 95% confidence interval. All related statistical analyses were performed using Comprehensive Meta-Analysis (CMA) software.

Results: A total of 13 articles were incorporated into the final meta-analysis. According to the current meta-analysis, curcumin plus piperine administration showed a significantly increased SOD activity and GSH levels while significantly decreased MDA concentrations. In addition, our study revealed that curcumin plus piperine significantly decreased TNF-α and IL-6 concentrations.

Conclusion: These results indicated that curcumin plus piperine administration could effectively reduce oxidative stress and inflammation.

Keywords: Curcumin; antioxidant; chronic disorders.; inflammation; meta-analysis; piperine.

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