Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Apr 1;24(1):220.
doi: 10.1186/s12887-024-04577-6.

Effects of sleep-disordered breathing on serum lipid levels in children:a case control study

Lei Lei  1 , XiaoYun Zhang  1 , Binbin Wang  1 , Fei Lei  2 , Li Dai  3 , Xiaoru Sun  1 , Yu Zhao  1 , Ping Zhu  4 , Jian Zou  5
Affiliations

Effects of sleep-disordered breathing on serum lipid levels in children:a case control study

Lei Lei et al. BMC Pediatr. .

Abstract

Background: Sleep-disordered breathing (SDB) during childhood is common and includes a range of breathing abnormalities that range from primary snoring (PS) to obstructive sleep apnea syndrome (OSAS).Studies have shown that not only OSAS, but also PS, which is originally considered harmless, could cause cardiovascular, cognitive, behavioral, and psychosocial problems. Many researches are focused on the relation of OSA and serum lipid levels. However, little studies are focused on PS and serum lipid levels in children.We evaluated whether serum lipid (total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C),low-density lipoprotein cholesterol (LDL-C)) concentrations were associated with specific components of SDB, including indices of oxygen reduction index, lowest oxygen saturation, mean oxygen saturation. And we explored whether serum lipid levels were associated with different degree sleep disordered (PS and OSA group) and obese.

Methods: This was a cross-sectional study. Children who were complained by their guardians with habitual snoring and(or) mouth breathing were collected in the SDB group. Normal children without sleep problem were matched in the control group. Subjects in the SDB group underwent polysomnography. The serum lipid profiles of all the children included TC, TG, HDL-C and LDL-C concentrations were measured by appropriate enzymatic assays.

Results: A total of 241 with Apnea/Hypopnea Index ≥ 5 (AHI) were assigned to the OSAS group and the remaining 155 with normal AHI were assigned to the PS group. The values of TC, TG, LDL-C and LDL/HDL were significantly higher in the OSAS group than in the PS group, and the values in the PS group were significantly higher than the control group. Multiple regression analysis revealed serum TG only correlated negatively with lowest oxygen saturation. Body mass index-z score has a positive effect on TG in all the 1310 children (P = 0.031) and in SDB 396 children(P = 0.012). The level of serum TG in obese group was significantly higher than that in non-obese group.

Conclusions: SDB had a very obvious effect on blood lipids, whereas PS without apnea and hypoxia. Obese only affects the aggregation of TG.

Trial registration: ChiCTR1900026807(2019.10.23).

Keywords: Children; Obese; Obstructive sleep apnea syndrome; Primary snoring; Serum lipid; Sleep-disordered breathing.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Similar articles

See all similar articles

Cited by

References

    1. Olsen M, Mignot E, Jennum PJ, Sorensen HBD, Robust. ECG-based detection of sleep-disordered breathing in large population-based cohorts. Sleep (2020)43: 1–11.10.1093/sleep/zsz276. - PubMed
    1. Kawano Y, Tamura A, Kadota J. Association between the severity of obstructive sleep apnea and the ratio of low-density lipoprotein cholesterol to high-density lipoprotein cholesterol. Metabolism. 2012;61:186–92. doi: 10.1016/j.metabol.2011.06.004. - DOI - PubMed
    1. Redline S, Storfer-Isser A, Rosen CL, Johnson NL, Kirchner HL, Emancipator J, et al. Association between metabolic syndrome and sleep-disordered breathing in adolescents. Am J Respir Crit Care Med. 2007;176:401–8. doi: 10.1164/rccm.200703-375OC. - DOI - PMC - PubMed
    1. Vlahandonis A, Walter LM, Horne RSC. Does treatment of SDB in children improve cardiovascular outcome? Sleep Med Rev. 2013;17:75–85. doi: 10.1016/j.smrv.2012.04.004. - DOI - PubMed
    1. de Sousa Caixêta JA, Saramago AM, de Cácia Pradella-Hallinan ML, Moreira GA, Tufik S, Fujita RR. Waist-to-height ratio distinguish obstructive sleep apnea from primary snoring in obese children. Sleep and Breathing. 2014;19:231–7. doi: 10.1007/s11325-014-1001-1. - DOI - PubMed