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. 1985 Mar;82(5):1499-502.
doi: 10.1073/pnas.82.5.1499.

Strong antitumor activities of IgG3 antibodies to a human melanoma-associated ganglioside

I Hellström, V Brankovan, K E Hellström

Strong antitumor activities of IgG3 antibodies to a human melanoma-associated ganglioside

I Hellström et al. Proc Natl Acad Sci U S A. 1985 Mar.

Abstract

Three mouse monoclonal IgG3 antibodies, 2B2, IF4, and MG-21, recognize a GD3 ganglioside antigen that is expressed at the cell surface of most human melanomas. All three antibodies mediate antibody-dependent cellular cytotoxicity (ADCC) in vitro when tested with human lymphocytes as effector cells in a 2-hr or 4-hr 51Cr-release test, and one antibody, MG-21, also gives strong complement-dependent cytotoxicity with human serum. Antibody 2B2, which gives ADCC also in the presence of mouse lymphocytes, inhibited the outgrowth of a human melanoma in nude mice, but antibody IF4, which showed no ADCC with mouse lymphocyte effectors, did not.

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