Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1985 Mar;82(5):1499-502.
doi: 10.1073/pnas.82.5.1499.

Strong antitumor activities of IgG3 antibodies to a human melanoma-associated ganglioside

I Hellström, V Brankovan, K E Hellström

Strong antitumor activities of IgG3 antibodies to a human melanoma-associated ganglioside

I Hellström et al. Proc Natl Acad Sci U S A. 1985 Mar.

Abstract

Three mouse monoclonal IgG3 antibodies, 2B2, IF4, and MG-21, recognize a GD3 ganglioside antigen that is expressed at the cell surface of most human melanomas. All three antibodies mediate antibody-dependent cellular cytotoxicity (ADCC) in vitro when tested with human lymphocytes as effector cells in a 2-hr or 4-hr 51Cr-release test, and one antibody, MG-21, also gives strong complement-dependent cytotoxicity with human serum. Antibody 2B2, which gives ADCC also in the presence of mouse lymphocytes, inhibited the outgrowth of a human melanoma in nude mice, but antibody IF4, which showed no ADCC with mouse lymphocyte effectors, did not.

PubMed Disclaimer

References

    1. Adv Immunol. 1974;18:67-132 - PubMed
    1. Proc Natl Acad Sci U S A. 1980 Apr;77(4):2183-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1980 Oct;77(10):6114-8 - PubMed
    1. J Immunol. 1981 Aug;127(2):539-46 - PubMed
    1. Int J Cancer. 1981 Mar 15;27(3):281-5 - PubMed

Publication types