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. 2024 Mar 28:19:589-597.
doi: 10.2147/CIA.S438541. eCollection 2024.

Characteristics and Prognosis of Type 2 Myocardial Infarction Through Worsening Renal Function and NT-proBNP in Older Adults with Pneumonia

Jinling Ma #  1 , Suyan Bian  1 , Ang Li  1 , Qian Chen #  1
Affiliations

Characteristics and Prognosis of Type 2 Myocardial Infarction Through Worsening Renal Function and NT-proBNP in Older Adults with Pneumonia

Jinling Ma et al. Clin Interv Aging. .

Abstract

Background: Type 2 myocardial infarction (MI) is becoming more recognized. This study aimed to assess the factors linked to type 2 MI in older adults with pneumonia and further determine the predictive factors of 90-day adverse events (refractory heart failure, cardiogenic shock, and all-cause mortality).

Methods: A single-center retrospective analysis was conducted among older adults with pneumonia. The primary outcome was the prevalence of type 2 MI. The secondary objective was to assess the adverse events in these patients with type 2 MI within 90 days.

Results: A total of 2618 patients were included. Of these, 361 patients (13.8%) suffered from type 2 MI. Multivariable predictors of type 2 MI were chronic kidney disease (CKD), age-adjusted Charlson comorbidity index (ACCI) score, and NT-proBNP > 4165pg/mL. Moreover, the independent predictive factors of 90-day adverse events included NT-proBNP > 4165pg/mL, age, ACCI score, and CKD. The Kaplan-Meier adverse events curves revealed that the type 2 MI patients with CKD and NT-proBNP > 4165pg/mL had a higher risk than CKD or NT-proBNP > 4165pg/mL alone.

Conclusion: Type 2 MI in older pneumonia hospitalization represents a heterogeneous population. Elevated NT-proBNP level and prevalence of CKD are important predictors of type 2 MI and 90-day adverse events in type 2 MI patients.

Keywords: mortality; older; pneumonia; type 2 myocardial infarction.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Associations of risk factors with type 2 MI in older adults with pneumonia.
Figure 2
Figure 2
Associations of risk factors with 90-day adverse events in older pneumonia patients of type 2 MI.
Figure 3
Figure 3
Kaplan–Meier 90-day adverse events (refractory heart failure, cardiogenic shock, and all-cause death) curves according to NT-proBNP level and CKD.
Figure 4
Figure 4
Kaplan–Meier 90-day adverse events (refractory heart failure, cardiogenic shock, and all-cause death) curves according to NT-proBNP level and CKD.
See this image and copyright information in PMC

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