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Review
. 2024 Apr 24;52(2):553-565.
doi: 10.1042/BST20230191.

Delineating mechanisms underlying parvalbumin neuron impairment in different neurological and neurodegenerative disorders: the emerging role of mitochondrial dysfunction

Elizaveta A Olkhova  1   2 , Laura A Smith  1   2 , Bethany H Dennis  3 , Yi Shiau Ng  1   2   4   5 , Fiona E N LeBeau  3 , Gráinne S Gorman  1   2   4   5
Affiliations
Review

Delineating mechanisms underlying parvalbumin neuron impairment in different neurological and neurodegenerative disorders: the emerging role of mitochondrial dysfunction

Elizaveta A Olkhova et al. Biochem Soc Trans. .

Abstract

Given the current paucity of effective treatments in many neurological disorders, delineating pathophysiological mechanisms among the major psychiatric and neurodegenerative diseases may fuel the development of novel, potent treatments that target shared pathways. Recent evidence suggests that various pathological processes, including bioenergetic failure in mitochondria, can perturb the function of fast-spiking, parvalbumin-positive neurons (PV+). These inhibitory neurons critically influence local circuit regulation, the generation of neuronal network oscillations and complex brain functioning. Here, we survey PV+ cell vulnerability in the major neuropsychiatric, and neurodegenerative diseases and review associated cellular and molecular pathophysiological alterations purported to underlie disease aetiology.

Keywords: interneurons; mitochondrial dysfunction; molecular mechanisms; neurodegeneration; oscillations; parvalbumin.

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Conflict of interest statement

The authors declare that there are no competing interests associated with the manuscript.

Figures

Figure 1.
Figure 1.. Dysfunction of PV+ neurons in neurological disorders.
Schematic representation of the role of PV+ neurons and congruent pathophysiological mechanisms contributing to neurodegeneration and gliosis in the major psychiatric and neurodegenerative diseases, under review (created with biorender.com).
See this image and copyright information in PMC

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