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Review
. 2024 Apr 2;73(5):94.
doi: 10.1007/s00262-024-03665-x.

Bifidobacterium modulation of tumor immunotherapy and its mechanism

Bo Pei #  1   2 , Shixuan Peng #  3 , Chuying Huang  2   4   5 , Fuxiang Zhou  6
Affiliations
Review

Bifidobacterium modulation of tumor immunotherapy and its mechanism

Bo Pei et al. Cancer Immunol Immunother. .

Abstract

The advent of tumor immunotherapy in patients has revolutionized the treatment of tumors and significantly improved survival rates for a wide range of tumors. However, the full therapeutic potential of immune checkpoint inhibitors (ICIs) has yet to be realized, as not all patients have a lasting survival benefit from them, and a significant proportion of patients show primary or acquired resistance to immunotherapy. Bifidobacterium is one of the most common probiotics, and its antitumor and immunomodulatory effects have been demonstrated in recent years, but its immunomodulatory effects in tumors, especially on ICIs and in combination, have not been extensively studied in clinical practice, and its effects on the immune system and the mechanisms that modulate immunotherapy are largely unknown. Therefore, this review will focus on the immunomodulatory effects of Bifidobacteria in malignancies and the possible mechanisms of action of Bifidobacteria on immunotherapy in the hope of providing a basis for further research and better application of Bifidobacteria in clinical practice.

Keywords: Bifidobacterium; Gut probiotics; Immune checkpoint inhibitors; Immunotherapy; Mechanism.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Fig. 1
Fig. 1
Bifidobacterium-modulatory cancer immunotherapy
Fig. 2
Fig. 2
Modulatory effects of Bifidobacteria in cancer immunotherapy
See this image and copyright information in PMC

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