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. 2024 Jun 25;8(12):3058-3062.
doi: 10.1182/bloodadvances.2023012309.

Thrombocytosis and megakaryocyte changes associated with PRCA

Joelle Abdallah  1 , Robert George Williams  1 , Hussein Awada  2 , Ganesh Raman  1 , Yusuf Ozcan  3 , Mark Orland  2 , Mutlu Mete  4 , Weina Chen  5 , Carmelo Gurnari  2   6 , Jaroslaw P Maciejewski  2 , Taha Bat  1
Affiliations

Thrombocytosis and megakaryocyte changes associated with PRCA

Joelle Abdallah et al. Blood Adv. .
No abstract available

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Conflict of interest statement

Conflict-of-interest disclosure: The authors declare no competing financial interests.

Figures

Figure 1.
Figure 1.
Proposed mechanism for PRCA-related thrombocytosis. (I) Proposed mechanism I: decreased erythropoiesis directs differentiation toward the megakaryocyte lineage. (II) Proposed mechanism II: increased EPO due to PRCA leads to synergistic signaling between EPO and TPO at bipotential MEP, stimulating TPO receptors and resulting in increased megakaryocyte formation. BFU, burst-forming unit; CFU, colony-forming unit; E, erythrocyte; Eo, eosinophil; GEMM, granulocyte-erythrocyte-monocyte-megakaryocyte; GM, granulocyte-monocyte; LT-HSC, long-term hematopoietic stem cell; MEG, megakaryocyte; MPP, multipotent progenitor, ST-HSC, short-term hematopoeitic stem cell. Figure created with BioRender.com.
See this image and copyright information in PMC

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