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. 1985 Mar;69(3):315-7.

Coagulopathy induced by continuous infusion of high doses of human lymphoblastoid interferon

  • PMID: 3856479

Coagulopathy induced by continuous infusion of high doses of human lymphoblastoid interferon

J Mirro Jr et al. Cancer Treat Rep. 1985 Mar.

Abstract

Seven patients with myeloblastic leukemia were treated for 10 days with high-dose (15 or 30 million units/m2/day), human lymphoblastoid interferon (Wellferon) by continuous iv infusion. All patients developed prolonged activated partial thromboplastin time, and four developed prolonged prothrombin time. Factor assays demonstrated low levels of II, VII, IX, X, and XII. Coagulation abnormalities improved after discontinuation of interferon therapy.

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