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Comparative Study
. 2024 Apr 4;62(10):2024-2029.
doi: 10.1515/cclm-2023-1018. Print 2024 Sep 25.

IgG and kappa free light chain CSF/serum indices: evaluating intrathecal immunoglobulin production in HIV infection in comparison with multiple sclerosis

Lars Hagberg  1   2 , Igal Rosenstein  2   3 , Jan Lycke  2   3 , Henrik Zetterberg  2   4   5   6   7   8 , Aylin Yilmaz  1   2 , Arvid Edén  1   2 , Magnus Gisslén  1   2   9
Affiliations
Free article
Comparative Study

IgG and kappa free light chain CSF/serum indices: evaluating intrathecal immunoglobulin production in HIV infection in comparison with multiple sclerosis

Lars Hagberg et al. Clin Chem Lab Med. .
Free article

Abstract

Objectives: To study intrathecal kappa free light chain (KFLC) synthesis in people living with HIV (PLWH) in comparison with multiple sclerosis (MS).

Methods: Cross-sectional analysis including 56 untreated and 150 well treated PLWH, and compared with 58 controls, and 223 MS patients.

Results: Elevated serum/cerebrospinal fluid (CSF) IgG and KFLC indices were observed in untreated PLWH. Seventy percent of untreated PLWH had KFLC index above 6.1, a threshold associated with clinically isolated syndrome/MS diagnosis. No association was found between KFCL index and CSF markers of neuronal injury in either PLWH or MS patients.

Conclusions: HIV-related immune system dysfunction is often associated with an elevated KFLC index akin to those observed in MS. HIV infection should be considered as a differential diagnosis for patients presenting with neurological symptoms and increased intrathecal immunoglobulin synthesis.

Keywords: HIV; MS diagnosis; cerebrospinal fluid; intrathecal immunoglobulin; kappa free light chain; multiple sclerosis.

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References

    1. Elovaara, I, Seppala, I, Poutiainen, E, Suni, J, Valle, SL. Intrathecal humoral immunologic response in neurologically symptomatic and asymptomatic patients with human immunodeficiency virus infection. Neurology 1988;38:1451–6. https://doi.org/10.1212/wnl.38.9.1451 . - DOI - PubMed
    1. Elovaara, I, Seppala, I, Kinnunen, E, Laaksovirta, H. Increased occurrence of free immunoglobulin light chains in cerebrospinal fluid and serum in human immunodeficiency virus-1 infection. J Neuroimmunol 1991;35:65–77. https://doi.org/10.1016/0165-5728(91)90162-z . - DOI - PubMed
    1. Chiodi, F, Asjo, B, Fenyo, EM, Norkrans, G, Hagberg, L, Albert, J. Isolation of human immunodeficiency virus from cerebrospinal fluid of antibody-positive virus carrier without neurological symptoms. Lancet 1986;2:1276–7. https://doi.org/10.1016/s0140-6736(86)92699-1 . - DOI - PubMed
    1. Gisslen, M, Fuchs, D, Svennerholm, B, Hagberg, L. Cerebrospinal fluid viral load, intrathecal immunoactivation, and cerebrospinal fluid monocytic cell count in HIV-1 infection. J Acquir Immune Defic Syndr 1999;21:271–6. https://doi.org/10.1097/00126334-199908010-00003 . - DOI - PubMed
    1. Gallo, P, Piccinno, MG, De Rossi, A, Pagni, S, Amadori, A, Chieco-Bianchi, L, et al.. Free light chains of immunoglobulins in the cerebrospinal fluid of human immunodeficiency virus type 1-infected patients. J Neuroimmunol 1990;26:229–38. https://doi.org/10.1016/0165-5728(90)90005-8 . - DOI - PubMed

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