Recurrent Giant Cell Tumor of Sphenoid Bone: A Rare Finding

Abstract

Giant Cell Tumors of the skull are rare and mostly occur in the middle cranial fossa. Radiological investigations serve as adjunct modalities; however, histopathological confirmation is mandatory. Ten to forty% of GCTs may be recurrent. Complete surgical resection is the treatment of choice, however, partial resection with adjuvant radiotherapy can serve as a secondary alternative. Recurrent cases require post-op radiotherapy. Here, we describe a case of recurrent giant cell tumor of sphenoid bone in a young male, who underwent surgical resection twice, after which he was advised adjuvant radiotherapy and denosumab. The patient did not take radiotherapy.

Keywords: Giant cell tumor (GCT); Sphenoid bone.

Fig. 1

Pre-op CEMRI showing T2 hyperintense mass measuring 4.1 × 4.3 × 4.5 cm (AP × TC × CC) involving both sphenoid sinus

Fig. 2

H & E stained (10x) showing singly scattered monomorphic round to spindle cells along with osteoclastic giant cells