Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jul 20;2(1):kyad010.
doi: 10.1093/discim/kyad010. eCollection 2023.

Friend or Foe - Tc17 cell generation and current evidence for their importance in human disease

Anna Veronika Hipp  1 , Bertram Bengsch  1 , Anna-Maria Globig  1
Affiliations
Review

Friend or Foe - Tc17 cell generation and current evidence for their importance in human disease

Anna Veronika Hipp et al. Discov Immunol. .

Abstract

The term Tc17 cells refers to interleukin 17 (IL-17)-producing CD8+ T cells. While IL-17 is an important mediator of mucosal defense, it is also centrally involved in driving the inflammatory response in immune-mediated diseases, such as psoriasis, multiple sclerosis, and inflammatory bowel disease. In this review, we aim to gather the current knowledge on the phenotypic and transcriptional profile, the in vitro and in vivo generation of Tc17 cells, and the evidence pointing towards a relevant role of Tc17 cells in human diseases such as infectious diseases, cancer, and immune-mediated diseases.

Keywords: IL-17; T cell; Tc17; Th17; inflammatory bowel disease.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1:
Figure 1:
Key features of Tc17 cells in protection and pathology
See this image and copyright information in PMC

References

    1. Annunziato F, Romagnani C, Romagnani S.. The 3 major types of innate and adaptive cell-mediated effector immunity. J Allergy Clin Immunol 2015, 135, 626–35. doi:10.1016/j.jaci.2014.11.001. - DOI - PubMed
    1. Mittrücker HW, Visekruna A, Huber M.. Heterogeneity in the differentiation and function of CD8+ T cells. Arch Immunol Ther Exp (Warsz) 2014, 62, 449–58. doi:10.1007/s00005-014-0293-y. - DOI - PubMed
    1. Mielke LA, Liao Y, Clemens EB, Firth MA, Duckworth B, Huang Q, et al. . TCF-1 limits the formation of Tc17 cells via repression of the MAF–RORγt axis. J Exp Med 2019, 216, 1682–99. doi:10.1084/jem.20181778. - DOI - PMC - PubMed
    1. Globig AM, Hipp AV, Otto-Mora P, Heeg M, Mayer LS, Ehl S, et al. . High-dimensional profiling reveals Tc17 cell enrichment in active Crohn’s disease and identifies a potentially targetable signature. Nat Commun 2022, 13, 3688. doi:10.1038/s41467-022-31229-z. - DOI - PMC - PubMed
    1. Liang Y, Pan H-F, Ye D-Q.. IL-17A-producing CD8+T cells as therapeutic targets in autoimmunity. Expert Opin Ther Targets 2015, 19, 651–61. doi:10.1517/14728222.2014.997710. - DOI - PubMed

LinkOut - more resources