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. 2024 Mar 19:14:1380716.
doi: 10.3389/fonc.2024.1380716. eCollection 2024.

A systematic review and meta-analysis of radiotherapy and particle beam therapy for skull base chondrosarcoma: TRP-chondrosarcoma 2024

Masatoshi Nakamura  1 , Masashi Mizumoto  1 , Takashi Saito  1 , Shosei Shimizu  2 , Yinuo Li  1 , Yoshiko Oshiro  1   3 , Masako Inaba  4 , Sho Hosaka  4 , Hiroko Fukushima  5 , Ryoko Suzuki  5 , Takashi Iizumi  1 , Kei Nakai  1 , Kazushi Maruo  6 , Hideyuki Sakurai  1
Affiliations

A systematic review and meta-analysis of radiotherapy and particle beam therapy for skull base chondrosarcoma: TRP-chondrosarcoma 2024

Masatoshi Nakamura et al. Front Oncol. .

Abstract

Introduction: Chondrosarcoma is a rare malignant bone tumor. Particle beam therapy (PT) can concentrate doses to targets while reducing adverse events. A meta-analysis based on a literature review was performed to examine the efficacy of PT and photon radiotherapy for skull base chondrosarcoma.

Methods: The meta-analysis was conducted using 21 articles published from 1990 to 2022.

Results: After PT, the 3- and 5-year overall survival (OS) rates were 94.1% (95% confidence interval [CI]: 91.0-96.2%) and 93.9% (95% CI: 90.6-96.1%), respectively, and the 3- and 5-year local control rates were 95.4% (95% CI: 92.0-97.4%) and 90.1% (95% CI: 76.8-96.0%), respectively. Meta-regression analysis revealed a significant association of PT with a superior 5-year OS rate compared to three-dimensional conformal radiotherapy (p < 0.001). In the studies used in the meta-analysis, the major adverse event of grade 2 or higher was temporal lobe necrosis (incidence 1-18%, median 7%).

Conclusion: PT for skull base chondrosarcoma had a good outcome and may be a valuable option among radiotherapy modalities. However, high-dose postoperative irradiation of skull base chondrosarcoma can cause adverse events such as temporal lobe necrosis.

Keywords: TRP; chondrosarcoma; meta-analysis; proton; skull base; systematic review; temporal lobe necrosis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Process for selection of articles.
Figure 2
Figure 2
Forest plots for (A) 3-year and (B) 5-year overall survival rates after particle beam therapy.
Figure 3
Figure 3
Forest plots for (A) 3-year and (B) 5-year local control rates after particle beam therapy.
See this image and copyright information in PMC

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